DEVELOPMENTAL PSYCHOPATHOLOGY

发展精神病理学模块的总体目标是阐明物质使用障碍（SUD）的精神病理前体和伴随物及其个体发生联系。在迄今进行的广泛研究的基础上，我们建议在未来5年内前瞻性地研究心理失调对发育特异性表现和成年期SUD结果的影响。在儿童和青少年表现为精神病理的特征中，破坏性行为障碍最明显地表现为非法药物使用和SUD的易感性。使用当代心理测量方法，该项目将开发一个由儿童破坏性行为障碍症状指示的结构，称为行为控制不足（BU）。这种构念被概念化为反映了一种具有发育特异性表现的持久特征。收集父母和后代的这一维度的指标，研究布鲁里溃疡从父母到孩子的传播。本研究将确定儿童期晚期和青春期SUD的精神病理前兆，并将确定从青春期到成年期的过渡对非法药物使用导致的SUD诊断的中介和调节影响。该模块将在养育做法和同伴选择的背景下确定布鲁里溃疡对青少年药物使用轨迹和sud的影响。在年轻的成年期，我们将检查额叶白质组织作为神经成熟的结果指标。我们将研究额叶白质组织对决策能力的实验室指标的影响。我们假设儿童布鲁里溃疡和青少年物质使用将预测年轻时白质发育不良和相关的决策能力缺陷

The overarching goal of the Developmental Psychopathology Module is to elucidate the psychopathological precursors and concomitants of substance use disorder (SUD) and their ontogenetic connections. Building on extensive research conducted to date, we propose in the next 5 years to prospectively examine the influences on developmentally specific manifestations of psychological dysregulation and adulthood SUD outcomes. Among characteristics manifested as psychopathology in childhood and adolescence, disruptive behavior disorders have been demonstrated most clearly to predispose to illicit drug use and SUD. Using contemporary psychometric methods, the project will develop a construct indicated by childhood disruptive behavior disorder symptoms, termed Behavioral Undercontrol (BU). This construct is conceptualized as reflecting a persistent trait with developmentally specific manifestations. The indicators of this dimension are collected from parents as well as offspring, and transmission of BU from parent to child will be studied. The research will identify psychopathological precursors of SUD in late childhood and adolescence, and will determine the mediating and moderating influences in the transition from adolescence to adulthood that portend SUD diagnoses resulting from illicit drug use. The Module will determine the influences of BU, in the context of parenting practices and peer selection, on adolescent substance use trajectories and SUDs. In young adulthood, we will examine frontal white matter organization as a neuromaturation outcome indicator. We will examine the influence of frontal white matter organization on laboratory indicators of decision-making competence. We hypothesize that childhood BU and adolescent substance use will predict white matter dysmaturation and associated deficits in decision-making competence in young adulthood, leading to severe and persistent SUDs consequent to illicit drugs.