Research Training in Infections and Immunity

描述（由申请人提供）：这份nssa竞争申请将允许贝勒医学院（BCM）的学员继续成功开展传染病临床研究事业。目前，我们是BCM或德克萨斯医学中心内唯一一家从事非艾滋病感染临床研究培训的NRSA。BCM在许多领域都有极好的培训机会。参与的项目具有良好的联邦资助记录和培训经验，包括：1)先天免疫和医院感染，2)基于新药，细胞和益生菌的治疗，3)病毒和细菌胃肠炎，4)病毒和细菌发病机制和肿瘤发生，5)急性呼吸道病原体和肺炎，6)疫苗开发和评估，7)结核病，8)假体感染。2007年参与NRSA计划的特定中心和项目的总拨款支持为1,950万美元。该计划的结构包括三个部分，代表了学员可以追求的培训轨道：1)实验室临床研究，2)临床研究试验和3)临床流行病学。所有在实验室学习的学员将被要求参加BCM的临床科学家培训计划（CSTP; K30）；实习医师将获得临床研究专业的硕士学位。那些追求临床流行病学的人需要进入德克萨斯大学休斯顿分校公共卫生学院（UTHSPH）并获得公共卫生硕士学位。修读临床试验课程的学员将分别进入CSTP或UTHSPH，并分别取得理学硕士或理学硕士学位。BCM的成人传染病培训计划表明，它可以吸引高素质的博士后学员，其中一半以上是女性，近四分之一是代表性不足的少数民族，并为他们提供在传染病临床研究中开始成功职业所需的技能。在当前周期内，该方案已培养了5名学员，他们都被任命为一所主要医学院或大学的助理教授。这些人总共发表了60篇经过同行评审的原创论文，并获得了几项享有盛誉的资助和职业发展奖项，总额达160万美元。这一成功的记录，加上申请人数翻了一番，以及10名新的教师导师/联合导师的参与，作为支持每年3名博士后学员的续签的证据，比当前周期的2名学员有所增加。

DESCRIPTION (provided by applicant): This NRSA competing application will allow trainees at Baylor College of Medicine (BCM) to continue to successfully launch clinical research careers in infectious diseases. At this time, ours is the sole NRSA existing within BCM or the Texas Medical Center to pursue clinical research training in non-AIDS infections. Superb training opportunities exist at BCM in a number of areas. Participating projects with a strong record of federal funding and training experience include: 1) Innate Immunity and Nosocomial Infections, 2) Novel Drug-, Cell- and Probiotic-based Therapeutics, 3) Viral and Bacterial Gastroenteritis, 4) Viral and Bacterial Pathogenesis and Oncogenesis, 5), Acute Respiratory Pathogens and Pneumonia, 6) Vaccine Development and Evaluation, 7) Tuberculosis, and 8) Prostheses Infections. Total grant support in 2007 for the specific centers and programs participating in this NRSA Program is $19.5M. The structure of the Program contains three components, representing training tracks that can be pursued by trainees: 1) laboratory-based clinical research, 2) clinical research trials and 3) clinical epidemiology. All trainees pursuing the laboratory-based track will be required to participate in the Clinical Scientist Training Program (CSTP; K30) at BCM; physician trainees will obtain their MS in Clinical Investigation. Those pursuing the clinical epidemiology track are required to enter the University of Texas-Houston School of Public Health (UTHSPH) and obtain their MPH. Those trainees pursuing the clinical trials track will enter either the CSTP or UTHSPH and obtain their MS or MPH, respectively. The Adult Infectious Diseases Training Program at BCM has shown it can attract highly qualified postdoctoral trainees, over half of them women and close to a quarter under-represented minorities, and provide them with the skills necessary to begin successful careers in infectious diseases clinical research. In the current cycle, this Program has graduated 5 trainees, all of whom were appointed to the Assistant Professor level in a major medical college or university. Altogether, these individuals have published 60 original peer-reviewed manuscripts and have been awarded several prestigious grants and career development awards, totaling $1.6M. This record of success, along with a doubling in the pool of applicants and the participation of 10 new Faculty Mentors/Co-Mentors, is offered as evidence in support of renewal with 3 postdoctoral trainees per year, an increase from 2 trainees in the current cycle.