Neurobiology and Neuropyschology of Aging

项目描述（由申请人提供）：博士生和博士后将在波士顿大学医学院（N=12）和哈佛医学院马萨诸塞州总医院（N=5）的神经生物学家、神经心理学家和神经影像学专家共17位导师的共同努力下，接受衰老神经生物学和神经心理学的全面培训。培训将包括以下方面的研究和教学：(1)正常衰老和年龄相关疾病的动物模型，(2)衰老和年龄相关神经疾病的神经心理学，以及(3)最新的神经成像技术。资源建立在广泛的研究活动和培训人员的赠款支持上，其中包括几个NIA资助的项目，两个阿尔茨海默病中心和20多个个人赠款。作为卡耐基博士项目的选定合作伙伴之一，通过路线图资助创建了第一批老龄化跨学科课程之一（跨学科系统科学导论：动态建模），神经成像基础的特定课程，以及生物医学科学教学的维萨里乌斯计划，该计划提供了衰老神经生物学方面独特而渐进的培训，从而获得了经验。培训干部的研究领域包括阿尔茨海默病和帕金森病的神经心理学和神经生物学（包括神经遗传学），非人灵长类动物模型的正常衰老和脑血管疾病，以及细胞、突触超微结构和神经影像学水平上与年龄相关的变化的研究。所有学生都将有动物模型（非人类灵长类动物和啮齿动物）和人类的培训经验，包括(1)神经心理学(2)结构和(3)成像研究。除其他特色外，该计划包括深入的课堂教学、以衰老为重点的神经科学方法、动手实验室研究、维萨里生物医学教学课程以及跨学科系统科学和动态建模课程。

DESCRIPTION (provided by applicant): Predoctoral and postdoctoral students will receive comprehensive training in the Neurobiology and Neuropsychology of Aging through the combined efforts of a total of 17 mentors that include neurobiologists, neuropsychologists and neuroimagers at Boston University School of Medicine (N=12) and Massachusetts General Hospital, Harvard Medical School (N=5). Training will include research and didactics in (1) animal models of normal aging and age-related disease, (2) neuropsychology of aging and age-related neurologic disease, and (3) state-of-the art techniques in neuroimaging. Resources are founded on extensive research activity and grant support of the trainers that include several NIA funded program projects, two Alzheimer Disease Centers, and over 20 individual grants. With experience gained through active participation as one of the selected partners in the Carnegie Initiative for the Doctorate, a Roadmap grant to create one of the first Interdisciplinary Courses in Aging (Introduction to Interdisciplinary Systems Science: Dynamic Modeling), specific courses in the Foundations of Neuroimaging, and the Vesalius Program in Teaching in the Biomedical Sciences, this program provides a unique and progressive training in the neurobiology of aging. The areas of research represented among the training cadre include the neuropsychology and neurobiology (including neurogenetics) of Alzheimer's disease and Parkinson's disease, normal aging and cerebrovascular disease in non-human primate models, and studies of age-related changes at the cellular, synaptic ultrastructure and neuroimaging levels. All students will have a training experience with animal models (non-human primates and rodent) and humans encompassing (1) neuropsychological (2) structural and (3) imaging studies. The program includes, among other features, in-depth classroom instruction, methods in neuroscience with an emphasis on aging, hands-on laboratory research, the Vesalius course in biomedical teaching, and a course in interdisciplinary systems science and dynamic modeling.