From Bench to Bedside: Molecular Stories of Research-Based Health Care

本项目的目标是开发以探究为基础的课程单元(ICU)，介绍 以分子结构为形式的“分子故事”的研究型保健。这些重症监护室将是 由MSOE生物分子建模中心工作人员组成的科学教育团队开发 (CBM)，一位有课程编写经验的资深教师，一位科学教育研究员，他将 开发评估工具，以陪同每个ICU和高中科学教师 熟悉ICU主题，具有身临其境的专业发展经验。 职业发展计划始于既定的暑期课程、基因、计划和 分子机器，更新教师对分子基本概念的内容知识 结构和功能。这个暑期课程之后是一个为期一周的建模研讨会， 老师们选择了一种有趣的人类疾病，并在创造的同时探索了疾病的分子基础 受影响蛋白质的物理模型。在下一学年，教师们将组织一场 智能团队(学生为研究主题建模)在其学校中，并直接与基础或 当地一所大学的临床研究人员创建了作为药物靶点的蛋白质的物理模型 治疗这种疾病。在接下来的暑假里，我们将深入探讨这种多重成分的分子基础 一种疾病及其治疗，老师们将作为ICU设计团队的成员参加。每个ICU 将遵循标准的查询驱动格式，为学生提供发现基本知识的机会 通过主动、动手的建模活动了解分子结构的概念。然后将这些知识应用到 以一种强调批判性思维技能的方式来适应临床情况。 在这个项目中开发的ICU将在演讲中广泛传播给其他教师 以及由CBM工作人员和参与教师通过蛋白质建模为学生举办的研讨会 威斯康星州科学奥林匹克竞赛的活动，在密尔沃基男孩和 女孩俱乐部，以及我们当地探索世界博物馆举办的一系列公开讲座中的成人学习者。 每个ICU的共同主题是NIH支持的基础和临床研究在 治疗人类疾病的新分子方法的发展。

The goal of this project is to develop Inquiry-based Curriculum Units (ICUs) that present basic concepts of molecular structure in the form of "molecular stories" of research-based health care. These ICUs will be developed by a team of science educators composed of staff of the MSOE Center for BioMolecular Modeling (CBM), a veteran teacher with curriculum writing experience, a science education researcher who will develop assessment instruments to accompany each ICU, and high school science teachers who are familiar with the ICU topic as a result of an immersive professional development experience. The professional development program begins with an established summer course, Genes, Schemes and Molecular Machines, which updates the teachers' content knowledge of basic concepts of molecular structure and function. This summer course is followed by a week-long Modeling Workshop in which teachers select an interesting human disease, and explore the molecular basis of the disease while creating physical models of the affected proteins. During the ensuing academic year, teachers will organize a SMART Team (Students Modeling A Research Topic) in their schools and interact directly with a basic or clinical researcher at a local university to create a physical model of the protein that serves as a drug target for the disease. In the summer following this multi-component, in-depth exploration of the molecular basis of a disease and its treatment, the teachers will participate as members of the ICU Design Team. Each ICU will follow a standard inquiry-driven format that provides opportunities for students to discover basic concepts of molecular structure through active, hands-on modeling activities. This knowledge is then applied to the clinical situation in a way that emphasizes critical thinking skills. The ICUs that are developed in this project will be broadly disseminated to other teachers in presentations and workshops given by CBM staff and the participating teachers, to students through a Protein Modeling event of the Wisconsin Science Olympiad , in an outreach program to students of the Milwaukee Boys & Girls Club, and to adult learners in a series of public lectures hosted by our local Discovery World Museum. The common theme of each ICU is the critical role played by NIH-supported basic and clinical research in the development of new molecular approaches to the treatment of human diseases.