DERIVING OOCYTES FROM ESCS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本提案的目的是评估猴多能干细胞对雌性生殖细胞谱系的贡献潜力，并探索获得适用于辅助生殖技术的功能性卵母细胞的可行性。 我们的主要假设是，灵长类动物多能干细胞来源于受精胚胎，通过体细胞核移植或iPS方法进行实验性重编程，能够在自发或定向分化后形成雌性生殖细胞和配子。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this proposal is to evaluate the potential of monkey pluripotent stem cells to contribute to the female germ cell lineage, and to explore the feasibility of deriving functional oocytes suitable for use in assisted reproductive technologies. Our main hypothesis is that primate pluripotent stem cells derived from fertilized embryos, experimentally reprogrammed by somatic cell nuclear transfer or iPS approaches are capable of forming female germ cells and gametes upon spontaneous or directed differentiation.