DEVELOPING A MODEL OF STRESS-INDUCED OBESITY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究的目的是开发程序，以更好地了解舒适食物摄入的神经机制。 摄入高热量的舒适食品以缓解社会环境压力导致肥胖流行的观点正在得到认可。 迄今为止，这表明社会环境因素，特别是与社会从属关系相关的心理社会压力，会影响雌性恒河猴的食欲。 猴子是社会性圈养的，那些处于从属社会地位的猴子表现出行为和内分泌压力指数。 雌猴的手腕皮下植入了一个电脑芯片，当它把手伸进自动喂食器时，就会识别出猴子，并提供一粒食物。 通过这种方式，每周7天，每天24小时监测食物摄入量。 在过去的一年中，我们发现，当在典型的低脂肪，高纤维猴子饮食（LCD）和高脂肪和糖饮食（HCD）之间进行选择时，占主导地位的雌性更喜欢HCD，但也继续吃LCD。 当只提供LCD时，占优势的动物消耗的卡路里数量与选择条件下相同。 从属动物也更喜欢HCD，但在选择条件下消耗的卡路里几乎是主导动物的两倍。 当选择被删除，下属继续消耗显着更多的热量的不太喜欢的液晶显示器。 行为研究表明，在去除HCD饮食后，焦虑样行为显着增加。 这些研究为社会环境变量如何导致人类过度食物消费和肥胖提供了见解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is designed to develop procedures to better understand the neural mechanisms for the ingestion of comfort foods. The notion that the ingestion of calorically dense comfort foods to relieve socio-environmental stressors contributes to the obesity epidemic is gaining acceptance. To date, this has showed that socio-environmental factors, notably the psychosocial stress associated with social subordination, affects appetite in female rhesus monkeys. Monkeys are housed socially and those of subordinate social status show behavioral and endocrine indices of stress. Females had a computer chip implanted subcutaneously in the wrist that, when reaching into an automated feeding dispenser would identify the monkey and deliver one pellet of food. In this way, food intake was monitored 24 hours per day, seven days a week. In the previous year, we showed that when given a choice between the typical low fat, high fiber monkey diet (LCD) and a diet high in fat and sugar (HCD), dominant females prefer the HCD but continue to eat the LCD as well. When presented with only the LCD, dominant animals consume the same number of calories as they did during the choice condition. Subordinates too preferred the HCD but consumed nearly twice as many calories during the choice condition as did the dominant animals. When the choice was removed, subordinates continued to consume significantly more calories of the less preferred LCD. Behavioral studies indicated that upon the removal of the HCD diet, anxiety-like behavior increased significantly. These studies are providing insights into how socio-environmental variable may contribute to excess food consumption and obesity in humans.