Pacific Northwest Udall Center

太平洋西北Udall中心(PANUC)是俄勒冈健康与科学大学和华盛顿大学的医生和科学家合作的企业，专注于认知障碍方面的丰富经验和专业知识，这是一种相对鲜为人知但具有破坏性的后果，在帕金森氏病(PD)患者中很常见。这个拟议中的新尤德尔中心将是俄勒冈州或WWAMl地区唯一的一个；WWAMI是太平洋西北地区各州合作安排的首字母缩写，华盛顿大学是该地区唯一的医学院和学术医疗中心：华盛顿、怀俄明州、阿拉斯加、蒙大拿州和爱达荷州。因此，PANUC将覆盖超过1300万美国人居住的整个美国的四分之一以上的面积。PANUC将实现NIH和NINDS的几个目标。PANUC是：非常以患者为导向，专注于PD的一个常见的非运动功能，了解相对较少，组织成高度相互关联的核心和项目，将促进临床、翻译和基础研究之间的新知识交流，急于为PD数据组织中心(PD-DOC)和科里尔研究所(Coriell Institute)做出全面贡献，提交给NINDS人类基因库，并由研究人员组成，尽管他们在两个机构工作，但仍有高度协作的生产力的长期记录。我们的任务是双重的。首先，PANUC将为PD患者以及他们的照顾者和医疗保健提供者提供服务。我们将提供更好的教育和临床护理，并提供参与临床研究的新机会。其次，PANUC将利用一系列来自成熟和合作实验室的尖端技术，发现和调查帕金森病认知障碍的潜在机制，为专注于帕金森病的科学家社区产生新的资源，并确定未来治疗开发的潜在目标。

The Pacific Northwest Udall Center (PANUC) is a collaborative enterprise among physicians and scientists at Oregon Health & Science University and the University of Washington that focuses considerable experience and expertise on cognitive impairment, a relatively poorly understood but devastating consequence that is common in patients afflicted with Parkinson's disease (PD). This proposed new Udall Center would be the only one in Oregon or the WWAMl region; WWAMI is an acronym for the cooperative arrangement among states in Pacific Northwest for which the University of Washington is the only medical school and academic medical center: Washington, Wyoming, Alaska, Montana, and Idaho. Thus, PANUC would cOver an area greater than one-fourth of the entire U.S.A. where more than 13 million Americans live. PANUC will achieve several goals of the NIH and NINDS. PANUC is: eminently patient-oriented, focused on a common non-motor feature of PD that is relatively poorly understood, organized into highly inter-related cores and projects that will promote exchange of new knowledge among clinical, translational, and basic research, anxious to contribute fully to the PD Data Organizing Center (PD-DOC) and the Coriell Institute for submission to the NINDS Human Genefics Repository, and composed of investigators who have a longstanding track record of highly collaborative productivity despite being at two institutions. Our mission is twofold. First, PANUC will serve PD patients, along with their caregivers and health care providers. We will provide improved education and clinical care, as well as offer new opportunities to participate in clinical research. Second, PANUC will discover and investigate the mechanisms that underlie cognitive impairment in PD using an array of cutting-edge technologies from accomplished and collaborative laboratories, generating novel resources for the community of scientists focused on PD, and identifying potential targets for future therapeutic development.