DIFFUSION TENSOR IMAGING OF AMYGDALO-FRONTAL PATHWAYS

在这个项目中，我们将评估大脑中白色物质连接的微观结构特性是否 与人类青少年和非人类灵长类动物的情绪调节异常有关。 扩散张量成像（DTI）将用于表征通路的白色微结构（主要是 通过钩束）在杏仁核和前额叶皮层之间，形成了主要的大脑 控制情绪的回路这个项目有四个目标。第一个目的是相关的DTI 测量猴子钩束的杏仁核反应性和慢性应激 曝光（与项目1）。我们预测，杏仁核反应性高和压力暴露的猴子 证明了在这个白色物质区域中最不正常的连接。第二和第三个目标是 相关的DTI措施，在钩束的良好特征的人类青少年群体。（项目2） 和3）皮质醇的儿科措施（项目2）和遗传与经验因素有关， 内化障碍（项目3）。我们预测，钩束的显微结构将异常， （a）儿童皮质醇慢性高水平，和（B）内化障碍风险的青少年。第四 目的是将钩束的DTI测量与情绪调节的fMRI测量相关联， 青少年（项目4）。我们预测，钩束的DTI特性将与 情绪调节任务的fMRI信号

In this project we will evaluate whether the microstructural properties of white matter connections in the brain are related to abnormalities in emotion regulation in both human adolescents and nonhuman primates. Diffusion tensor imaging (DTI) will be used to characterize white matter microstructure of pathways (primarily through the uncinate fasciculus) between the amygdala and prefrontal cortex, which form the primary brain circuitry for emotion regulation. There are four aims of this project. The first aim is to related DTI measurements in the uncinate fasciculus of monkeys to measures of amygdala reactivity and chronic stress exposure (with Project 1). We predict that monkeys with high amygdala reactivity and stress exposure will demonstrate the most abnormal connections in this white matter region. The second and third aims are to relate DTI measures in the uncinate fasciculus of well-characterized human adolescent groups. (Projects 2 and 3) to pediatric measures of cortisol (Project 2) and genetic versus experiential factors related to internalizing disorders (Project 3). We predict that the uncinate fasciculus microstructure will be abnormal in adolescents with (a) high chronic levels of pediatric cortisol, and (b) risk of internalizing disorders. The fourth aim is to relate DTI measures in the uncinate fasciculus with fMRI measures of emotion regulation in adolescents (Project 4). We predict that the DTI properties of the uncinate fasciculus will be related to the fMRI signals in response to emotion regulation tasks