NICHD Cooperative Multicenter Neonatal Research Network

描述（由申请人提供）：爱荷华大学提交此更新申请，继续参与NICHD合作多中心新生儿研究网络（RFA-HD-10-003）。我们为网络提供五个特殊优势。 1.我们的新生儿重症监护室的临床结果是一流的-在世界上最好的。我们的极低出生体重儿死亡率在新生儿研究网络中常年最低。由于我们的低死亡率和高随访率，我们在随访中看到的极低出生体重婴儿与一些更大的网络中心一样多。 2.我们在新生儿和婴儿临床研究方面有着悠久的传统和重要贡献的记录。在产科单位和新生儿重症监护室，我们有一个强大的基础设施，进行和支持临床研究，有助于我们的生产力。 3.我们在遗传学领域拥有大量的专业知识和资源，包括我们于1999年创建的围产期研究DNA库。我们的DNA库和其他机构的样本正在用于研究新生儿疾病的遗传影响。在我们进入网络的前5年里，我们的研究人员之一Jeff Murray博士与网络中的其他人合作，在整个网络范围内应用遗传学和基因组学方法，包括应用程序开发一个前瞻性的DNA库。 4.作为一个主要以农业为基础的农村国家中唯一的学术医疗中心，我们代表的人口在NICHD网络中没有得到很好的代表。如果要将网络研究的结果推广到全国各地的患者，则应代表该国的这一大片地区。爱荷华大学网络中心代表了这一地区和人口。 5.在过去的5年里，我们作为网络中心表现非常出色。我们贡献了当前资助周期中提交的新项目的约1/6。我们的ELBW死亡率是网络中最低的，我们的死亡或神经发育障碍的复合结局率最低。我们的后续行动率在该网络中名列前茅。自从今年年初我们增加了第二个站点以来，我们在通用数据库中的患者登记人数增加了一倍多。 公共卫生相关性：新生儿医学中的许多关键问题只能通过大型多中心临床试验来解决。申请研究者和机构坚定地致力于多中心临床试验的概念，将其作为评估新疗法的最有力工具。我们认为，我们有责任参与这些试验，我们完全赞同NICHD新生儿研究网络的愿景。

DESCRIPTION (provided by applicant): The University of lowa submits this renewal application for continued participation in the NICHD Cooperative Multicenter Neonatal Research Network (RFA-HD-10-003). We offer five special strengths to the Network. 1. Our NICU's clinical outcomes are superb - among the best in the world. Our VLBW mortality is perennially the lowest in the Neonatal Research Network. With our low mortality and high follow-up rate, we see as many as VLBW infants in follow-up as some much larger Network centers. 2. We have a strong tradition and track record of important contributions in clinical research in neonates and infants. In the obstetrics units and the NICU, we have a robust infrastructure for the conduct and support of clinical research that has contributed to our productivity. 3. We have considerable expertise and resources in the area of genetics, including our Perinatal Research DNA Bank, which was created in 1999. Samples from our DNA Bank and others are being used for research on the genetic influences of neonatal disease. During our first 5 years in the Network, one of our investigators, Dr. Jeff Murray, has worked with others in the Network to apply genetics and genomics approaches on a Network-wide scale, including the application to develop a prospective DNA repository. 4. As the only academic medical center in a largely rural state with an economy based in agriculture, we represent a population that is not otherwise well represented in the NICHD Network. If the results of Network studies are to be generalized to patients throughout the country, this large area of the country should be represented. The University of lowa Network center represents this region and population. 5. We have performed extremely well as a Network center during the past 5 years. We have contributed approximately 1/6 of the new projects submitted in the current funding cycle. Our ELBW mortality rates are the lowest in the Network, and we have the lowest rate of the composite outcome of death or neurodevelopmental impairment. Our follow-up rate is among the highest in the Network. Our patient enrollment in the Generic Database has more than doubled since we added a second site early this year. PUBLIC HEALTH RELEVANCE: Many crucial questions in neonatal medicine can only be addressed by large multicenter clinical trials. The applicant investigators and institution are firmly committed to the concept of multicenter clinical trials as the most powerful tool for evaluating new therapies. We believe it is our responsibility to offer our participation in such trials, and we fully subscribe to the vision of the NICHD Neonatal Research Network.