Training Program in Bioinformatics

描述（由申请人提供）：这是一项更新和发展密歇根大学（UM）生物信息学培训计划（BTP）的建议，该计划目前每年资助6名实习生，用于2-3年的博士前培训，在我们的密歇根大学范围内计算医学和生物信息学中心（CCMB）。BTP是生物信息学和计算生物学的跨学科研究生培训计划，吸引了医学院，工程学院，文学，科学和艺术学院（LS&A;包括数学，统计学，化学和物理学系），公共卫生学院，药学院和信息学院的教师。BTP的目标是培养学生在生物信息学和应用计算生物学通过从事他们在一个严格的课程和博士前培训经验，所有的同时从事尖端的合作研究具有强大的“驱动生物问题”（DBP）的应用，往往导致BTP学员有一个强大的T1转化研究方向。BTP论文培训采用“双导师”方法，结合了定量/计算和DBP应用元素。基于UM的NIH国家综合生物医学信息学中心（NCIBI），癌症生物信息学，蛋白质组信息学活动和CTSA生物医学信息学计划都获得了国家认可，并且是我们的学员和教师的天然磁铁。自2001年成立以来，BGP现已发展到38个博士学位。学生和6个MS，17个博士学位。授予14个MS学位。现在是第五个年头，BTP现在已经为其中13名学生的支持做出了贡献，预计本学年将有前3名毕业生。更新UM BTP将使我们能够维持我们在这个高度专业化的领域培养有前途的学生的能力，他们将发展必要的技能和知识，以在学术界，工业界和政府的基础和应用研究中成功和独立的职业生涯。CCMB，BGP和BTP都非常积极地与全国各地的少数民族机构研究中心（RCMI）计划机构合作建立强大的少数民族招聘渠道。密歇根大学对生物信息学和计算生物学的机构支持非常强大，为BTP在这一拟议的5年期及可预见的未来蓬勃发展奠定了稳定的基础。 公共卫生相关性：生物信息学和计算医学，重点是生物信息学的基础和转化方面，因为它被应用于有意义的生物和临床问题，是一个快速增长的领域。有一个严格训练的博士生在分析，整合和组织数字数据集从下一代测序，基因表达，蛋白质组学和代谢组学平台在这些应用环境中的专业知识的需求不断增长（S）。

DESCRIPTION (provided by applicant): This is a proposal to renew and grow the University of Michigan (UM) Bioinformatics Training Program (BTP), which currently funds 6 trainee slots/year for 2-3 years of pre-doctoral training, within our University of Michigan-wide Center for Computational Medicine and Bioinformatics (CCMB). The BTP is an interdisciplinary graduate training program in bioinformatics and computational biology, drawing faculty from the School of Medicine, College of Engineering, Literature, Sciences and the Arts (LS&A; Including the Departments of Mathematics, Statistics, Chemistry, and Physics), the School of Public Health, the College of Pharmacy, and the School of Information. The goal of the BTP is to train students in bioinformatics and applied computational biology by engaging them in a rigorous curriculum and pre-doctoral training experience, all the while engaging in cutting-edge collaborative research featuring a strong "driving biological problem" (DBP) application, often leading BTP trainees to have a strong T1 Translational Research orientation. The BTP dissertation training utilizes a "dual-mentor" approach, which combines quantitative/computational and DBP application elements. The UM-based NIH National Center for Integrative Biomedical Informatics (NCIBI), cancer bioinformatics, proteome informatics activities, and CTSA Biomedical Informatics Program have all achieved national recognition, and are a natural magnet for our trainees and faculty. Since its inception in 2001, the BGP has now grown to 38 Ph.D. students and 6 MS, with 17 Ph.D. and 14 MS degrees conferred. Now in its fifth year, the BTP has now contributed to the support of 13 of these students, with the its first 3 graduates expected this academic year. Renewing the UM BTP will enable us to sustain our ability to train promising students in this highly specialized domain who will develop the skills and knowledge necessary to launch successful and independent careers in basic and applied research in academia, industry, and government. The CCMB, BGP, and the BTP are all very actively building a robust minority recruitment pipeline in partnership with the Research Centers for Minority Institutions (RCMI) program institutions across the nation. Institutional support for bioinformatics and computational biology at the U-M is very strong, forming a stable base for the BTP to thrive in this proposed 5-year period and beyond into the foreseeable future. PUBLIC HEALTH RELEVANCE: Bioinformatics and Computational Medicine, which focuses on the basic and translational aspects of bioinformatics as it is applied to meaningful biological and clinical problems, is a rapidly growing field. There is a growing need for rigorously-trained doctoral students with expertise in analyzing, integrating, and organizing digital datasets from next-generation sequencing, gene expression, proteomics and metabolomic platforms within these application context(s).