Training Program in Translational Cardiovascular Science

描述（由申请人提供）： 本申请要求继续支持威斯康星大学麦迪逊分校威斯康星州心血管研究中心（CVRC）11-15年级的转化心血管科学培训项目。CVRC位于医学与公共卫生学院（SMPH），是一个校园范围内的跨学科研究中心，拥有来自其他七所学校和学院以及27个学术部门的教职员工。所有这些机构都致力于发展有关心血管疾病基础的基础研究、临床研究、诊断和治疗和/或公共教育的项目。该培训计划为博士后MD和博士（四个职位）以及博士前学员（四个职位，要求增加一个职位）提供基础研究培训，目标是培养能够从分子到床边思考和工作的科学家。“实际的直接目标是吸引和培训基础研究的临床医生，并吸引和培训临床基础科学的研究生和博士后（博士）学生。此应用程序请求支持医生的研究培训，作为其住院医师和同事培训的一部分。该培训计划还资助转化心血管科学的博士前和博士后（PhD）学员。该计划中的24名培训师是从CVRC成员中选出的，因为他们在重点领域（收缩性/心力衰竭，离子通道/心律失常和血管生物学/动脉粥样硬化和细胞生物学/干细胞）的科学的临床相关性，他们的培训记录，以及他们的同行评审研究计划的整体活动和影响。培训发生在威斯康星大学麦迪逊分校，并利用强大的机构支持和环境，这种培训，以及临床和基础科学部门和教师之间建立的工作关系都在医学和公共卫生学院和大学。培训师和学员都参与核心活动，将该计划定义为一个有凝聚力的实体。在这个转化心血管科学计划中培训的科学家和医生科学家处于独特的地位，可以应用基本的科学知识来造福心血管疾病患者，心血管疾病是美国人死亡的首要原因。

DESCRIPTION (provided by applicant): This application requests continuing support for Years 11-15 for the Training Program in Translational Cardiovascular Science within the University of Wisconsin Cardiovascular Research Center (CVRC) at the University of Wisconsin-Madison. Housed in the School of Medicine and Public Health (SMPH), the CVRC is a campus-wide interdisciplinary research center with faculty members from seven additional schools and colleges and from 27 academic departments. All are dedicated to developing programs in basic research, clinical investigation, diagnosis and therapy, and/or public education concerning the basis for cardiovascular diseases. The training program provides basic research training for postdoctoral MD's and PhD's (four positions), as well as predoctoral trainees (four positions, with a request for one additional slot), with the goal of training scientists who will be capable of thinking and working "from molecule to bedside." The practical immediate aims are to attract and train clinicians in basic research, and to attract and train graduate and postdoctoral (PhD) students in clinically motivated basic science. This application requests support for research training of physicians as part of their resident and fellow training. The training program also funds predoctoral and postdoctoral (PhD) trainees in translational cardiovascular sciences. The 24 trainers in this program have been selected from members of the CVRC for the clinical relevance of their science in the focus areas (contractility/heart failure, ion channels/arrhythmias and vascular biology/atherosclerosis and cell biology/stem cells), their training records, and the overall activity and impact of their peer-reviewed research programs. Training takes place at UW-Madison and takes advantage of the strong institutional support and environment for such training, as well as the established working relationships between clinical and basic science departments and faculty both within the School of Medicine and Public Health and the University at large. Trainers and trainees all participate in core activities that define the program as a cohesive entity. The scientists and physician scientists trained in this translational cardiovascular science program are in unique positions to apply basic scientific knowledge to benefit patients with cardiovascular disease, the foremost cause of mortality among Americans.