Training Program in Neuroscience

描述（由申请人提供）：拟议的神经科学培训计划将为未来的博士生提供由国内和国际公认的教师讲授的令人兴奋的课程，以及建立在转化神经科学，基础神经生物学，精神病学和神经病学专业知识基础上的实验室经验，由于西奈山医院和西奈山医学院的临床和基础神经科学研究紧密相关，所有这些都独特地相互“接口”。培训计划的核心是西奈山的神经科学博士学位，这是该校的第二个博士学位授予项目（生物医学科学是第一个），该项目由纽约大学研究生院认可，并于2007年获得纽约州批准。参与培训的教师有一个共同的主题兴趣：研究特定神经回路的功能和可塑性，在发育过程中，在成人，在老年，患病或退化的神经系统。西奈山医学院的各种实验室机会充分利用了转化神经科学的特殊优势，特别是在发育神经生物学、神经衰老和退化、神经精神疾病机制、认知神经科学、计算神经科学和神经成像、感觉信号转导、神经内分泌学以及突触和行为可塑性方面。神经系统在不同的模型系统中被研究，从“简单”的无脊椎动物，如海蜗牛、果蝇或线虫，一直到复杂的脊椎动物，包括非人灵长类动物和人类。学生将在积极促进多学科综合研究的协作环境中获得基础神经生物学的坚实基础。采用这种跨学科的方法，神经科学培训计划将为四名学生提供必要的知识和实验工具，以在我们的培训教师的实验室中开始富有成效的独立职业生涯。

DESCRIPTION (provided by applicant): The proposed Neuroscience Training Program will offer prospective predoctoral students an exciting curriculum taught by a nationally and internationally recognized faculty, and a laboratory experience that builds on expertise in translational neuroscience, basic neurobiology, psychiatry, and neurology, all uniquely 'interfaced' with one another due to close apposition of clinical and basic neuroscience research at the Mount Sinai Hospital and Mount Sinai School of Medicine. At the heart of the Training Program is Mount Sinai's Neuroscience Ph.D., the school's second Ph.D. granting program (Biomedical Sciences being the first), that was endorsed by the New York University Graduate School and approved by New York State in 2007. Participating training faculty share a common thematic interest: study of the function and plasticity of specific neural circuits, during development, in the adult, and in the aged, diseased or degenerating nervous system. Varied laboratory opportunities at Mount Sinai School of Medicine take advantage of particular strengths in translational neuroscience, notably in developmental neurobiology, neural aging and degeneration, mechanisms of neuropsychiatric disease, cognitive neuroscience, computational neuroscience and neuroimaging, sensory signal transduction, neuroendocrinology and synaptic and behavioral plasticity. The nervous system is studied in diverse model systems, from 'simple' invertebrates such as the sea snail Aplysia, the fruit fly, or the worm C. elegans, all the way to complex vertebrates including nonhuman primates and humans. Students will receive a solid foundation in basic neurobiology, in a collaborative environment that actively promotes multidisciplinary, integrative research. Using this interdisciplinary approach, the Neuroscience Training Program will provide four students with the essential knowledge and experimental tools to initiate productive, independent careers in the laboratories of our training faculty. RELEVANCE: An estimated four million Americans suffer from Alzheimer's disease, other neurodegenerative conditions including Parkinson's disease, and neuropsychiatric disease, which cumulatively represent an incredible public health burden. The proposed Neuroscience Training Program will educate talented young scientists, thus providing a firm foundation for productive, independent careers in neuroscience research and teaching.