Training Grant in Neurodevelopmental Disabilities

描述（由申请人提供）：项目摘要：我们的跨学科机构培训计划在神经发育障碍，在费城儿童医院（CHOP）和宾夕法尼亚大学（P的U）的目的，是培养医学博士和博士前/博士后研究员集中在遗传和后天性疾病，导致精神发育迟滞和发育障碍。27名导师将参加该计划的第二次竞争性更新; 20人主要在CHOP，7人主要在P. U所有人都积极参与生物医学研究生教育，并通过相互研究项目和赠款密切相关。除了指导研究培训，我们的课程强调：1）医学博士和博士的临床实习要求，2）通过P研究生课程的U正式课程工作，3）负责进行研究的培训，4）生物统计学培训和5）涵盖各种重要生存技能的研讨会，包括科学写作，公开演讲，赠款写作研讨会，实验室管理和职业发展技能。在我们计划的前9年，我们接受了19名学员; 4名是医学博士，14名是博士，1名是医学博士/博士。这些受训人员中有11人是女性，4人是代表性不足的少数民族。在14名完成培训的人中，8人担任教职，2人在其他学术机构继续接受培训，1人是制药公司的高级研究科学家，1人是科学管理人员，1人私人执业。我们要求继续支持4博士后研究员/年，并希望扩大我们的计划，包括支持2博士前研究员/年。我们的目标仍然集中在提供一个培训计划，不同于任何其他在这里CHOP或P的U，重点是后天和遗传原因的发育障碍。该计划受益于在一个优秀的环境，承诺大量资源的培训，基础生物医学研究，并以真正的“板凳到床边”的方法转化研究。项目相关性：据估计，发育障碍影响美国10%的家庭。迫切需要愿意并能够应用现代研究方法来阐明这些疾病的发病机制和病理生理学的研究人员，以便确定新的和更有效的治疗干预措施。该计划旨在满足这一需求。

DESCRIPTION (provided by applicant): Project Summary: The aim of our interdisciplinary Institutional Training Program in Neurodevelopmental Disabilities, based at The Children's Hospital of Philadelphia (CHOP) and The University of Pennsylvania (U of P), is to train MD and PhD pre-/post-doctoral fellows in research focused on genetic and acquired disorders that cause mental retardation and developmental disability. Twenty-seven mentors will participate in this second competitive renewal of this program; 20 are based primarily at CHOP, and 7 primarily at the U of P. All are heavily involved in biomedical graduate education and are closely interlinked by mutual research projects and grants. In addition to mentored research training, our curriculum emphasizes: 1) a clinical practicum requirement for both MDs and PhDs, 2) formal course work through the U of P Graduate Studies Program, 3) training in responsible conduct of research, 4) training in biostatistics and 5) workshops that cover a variety of important survival skills, including scientific writing, public presentations, grant writing workshops, laboratory management, and career advancement skills. During the first 9 years of our program, we accepted 19 Trainees; 4 were MDs, 14 were PhDs, and 1 was a MD/PhD. 11 of these trainees were female and 4 of these trainees were under-represented minorities. Of the 14 who have completed training, 8 are in faculty positions, 2 are continuing their training at other academic institutions, 1 is a senior research scientist at a pharmaceutical company, 1 is a scientific administrator, and 1 is in private practice. We request continued support for 4 postdoctoral fellows/year and would like to expand our program to include support for 2 pre-doctoral fellows/year. Our goal remains focused on providing a training program unlike any other here at the CHOP or the U of P that is focused on acquired and genetic causes of developmental disability. This program benefits from being in an outstanding environment that commits substantial resources to training, to basic biomedical research, and to a true 'bench to bedside' approach to translational research. Project Relevance: It has been estimated that developmental disabilities affect 10% of all families in the USA. Researchers are urgently needed who are willing and able to apply modern research methods to elucidating the pathogenesis and pathophysiology of these disorders, so that new and more effective therapeutic interventions can be identified. This program strives to fill this need.