Men's INTernet Study III (MINTS-III) for HIV Prevention

描述(由申请人提供)：MINTS-III是根据PA-07-295重新提交的竞争性续签申请。它建立在MINTS-I和MINTS-II的基础上，MINTS-I是对MSM中互联网和艾滋病毒风险的首批调查研究之一；MINTS-II开发和测试了Sexpulse，这是一种针对使用互联网寻求与男性发生性行为的男性(MISM)的在线艾滋病毒预防干预措施。MINTS-II是MISM的第一个在线随机对照试验，报告了12个月以上的可接受保留和短期疗效。在3个月的随访中，干预组报告的危险行为的减少明显大于空白对照组(20%)。我们还观察到控制组报告的风险行为显著减少，我们假设这是小组条件反射的产物。薄荷糖-III是这一前景广阔的研究领域合乎逻辑的下一步。我们的第一个目标是通过增加Sexpulse的剂量来增加干预的长期预防艾滋病毒的有效性。以用户为中心的干预设计迭代将包含对个人风险行为的个性化、量身定做的反馈；将研究调查整合到干预中；并添加后续助推器，所有这些都旨在提高长期行为有效性。在目标2中，我们提出了两个子研究来检验性危险行为在线测量的可靠性和有效性。目的3在1000名高危MISM的随机对照试验中，测试强化干预、Sexulse 1.1和助推剂的长期风险降低效果。这一随机对照试验设计通过三个级别的招募得到了加强，以便在目标4中，我们可以研究风险衡量的威胁，特别是小组调节。我们的最终目标是在500例无风险/低风险MISM的随机对照试验中测试Sexpulse 1.1(包括在线助推器)的长期保护效果。在成功实现这些目标后，Sexpulse 1.1应该是一种强有力的、被证明有效的干预措施，可以从战略上定位于传播。 公共卫生相关性：PA-07-295要求“进行有针对性的研究，以测试经过调整的‘基于互联网’干预措施的有效性，互联网和其他技术作为向消费者提供健康信息的机制的有效性，以及技术使用对消费者健康的影响。”对科学的意义包括测试措施和方法，以研究在线艾滋病毒风险评估中的反应偏差。对公共健康的意义包括对一种有前景的干预措施进行严格测试，作为一种降低风险和保护MSM的干预措施，MSM是美国受艾滋病毒影响最严重的人群。推进艾滋病毒预防的创新方法的意义包括测试一种基于计算机游戏理论的艾滋病毒预防的新方法，这种方法在目前信息丰富但没有参与艾滋病毒预防的人群中似乎很有希望。

DESCRIPTION (provided by applicant): MINTS-III is a competing continuation application resubmission in response to PA-07-295. It builds upon MINTS-I, one of the first survey studies of the Internet and HIV risk among MSM; and MINTS-II, which developed and tested Sexpulse, an online, HIV prevention intervention for Men who use the Internet to seek Sex with Men (MISM). MINTS-II is the first online RCT of MISM to report acceptable retention over 12 months and short-term efficacy. At the 3-month follow-up, the intervention group reported a significantly greater (20%) reduction in risk behavior than the null control. We also observed a significant reduction in reported risk behavior in the control group, which we hypothesize is the product of panel conditioning. MINTS-III is the logical next step in this promising area of research. Our first aim is to increase the long-term HIV prevention effectiveness of the intervention by strengthening the dosage of Sexpulse. A substantial user-centered design iteration of the intervention will incorporate personalized, tailored feedback on individual risk behavior; integrate research surveys into the intervention; and add follow-up boosters all aimed at increasing the long-term behavioral effectiveness. In Aim 2, we propose two sub-studies to examine the reliability and validity of online measures of sexual risk behavior. Aim 3 tests the long-term risk reduction efficacy of the strengthened intervention, Sexpulse 1.1, and boosters, in an RCT of 1000 high-risk MISM. This RCT design has been enhanced by three levels of recruitment so that in Aim 4, we can study threats to risk measurement, especially panel conditioning. Our final aim tests the long-term protective efficacy of Sexpulse 1.1 (including online boosters) in an RCT on 500 no/lower risk MISM. Upon successful completion of these aims, Sexpulse 1.1 should be a strong and demonstrated-effective intervention that can be strategically positioned for dissemination. PUBLIC HEALTH RELEVANCE: PA-07-295 calls for "targeted research to test the effectiveness of adapted 'Internet-based' interventions, the effectiveness of the Internet and other technologies as a mechanism to deliver health information to consumers, and the impact of technology use on consumer health." The significance to science includes testing measures and methods to study response bias in online HIV risk assessments. The significance to public health includes rigorous testing of a promising intervention as both a risk reduction and protection intervention for MSM, the population most affected by HIV in the US. The significance to advancing innovative methods of HIV prevention includes testing a new approach to HIV prevention based on computer gaming theory that appears promising in a population currently well-informed but disengaged from HIV prevention.