20-year intergenerational longitudinal followup of females abused as children

描述（由申请人提供）：很少有纵向队列跨越多个发展阶段和跨越几代人。pi成功地保留了96%的经历过儿童期性虐待的女性样本（N=84）和人口统计学上相似的对照组（N=89） 20年；完成儿童期/青春期早期3次（T1-T3）、青春期后期/成年初期2次（T4 & T5）、成年早期1次（T6）的综合生物心理评估。我们还评估了该样本所有已知后代的91% （N=135）。迄今所取得的成果对关于虐待对妇女发展的影响的长期后果和代际转移的文献作出了重大贡献。另一项后续评估（T7）将采用新技术（包括远程网络和基于pc的评估工具）和新兴理论模型（包括风险和恢复力的geneXenvironment和激素模型），这将使我们能够做出更多贡献。然而，为了生产针对T7后续的最具竞争力的R01，我们必须首先确定试点新兴创新方法的可行性，并从样本中确定他们可以/将参与的方式以及后代样本的人口构成，因为它现在组成。此外，这是一个特别脆弱的人群，所以我们花时间仔细和敏感地将新兴技术（特别是遗传学）整合到我们的协议中是至关重要的。因此，本申请旨在开发创新方法和新技术，以推进发展研究，并建议评估利用这些技术的可行性，以完成对儿童虐待对女性发展影响的最长、正在进行的20年跟踪研究。这项可行性研究将为一个高度创新的、具有竞争力的R01奠定基础，旨在测试在整个发展过程中以及在童年时期受虐待的女性及其家庭中跨代的风险和恢复能力的综合基因环境和生物-心理-社会模型。

DESCRIPTION (provided by applicant): Few longitudinal cohorts span multiple developmental stages and extend across generations. The PIs have been successful at retaining 96% of a sample of females who experienced substantiated childhood sexual abuse (N=84) and a demographically similar comparison group (N=89) for 20 years; accomplishing comprehensive bio-psychological assessments three times (T1-T3) in childhood/early adolescence, twice (T4 & T5) in later adolescence/emerging adulthood, and once in young adulthood (T6). We have also assessed 91% of all known offspring born to the sample (N=135). Results generated thus far have contributed substantially to the literature on the long-term sequelae and intergenerational transference of the effects of abuse on female development. An additional followup assessment (T7) which would employ new technologies (including remote web and PC-based assessment tools) and emerging theoretical models (including geneXenvironment and hormone models of risk and resilience) will allow us to contribute much, much more. However, in order to produce the most competitive R01 aimed at a T7 followup, we must first establish feasibility in piloting emergent, innovative methodologies and ascertain from the sample both the ways in which they can/will participate and the demographic make up of the offspring sample as it is now comprised. Further, this is a particularly vulnerable population so it is vitally important that we take the time to carefully and sensitively integrate emerging technologies (genetics in particular) into our protocols. Hence, this application seeks to develop innovative methodologies and new technology to advance developmental research and proposes to evaluate the feasibility of utilizing these techniques to accomplish the 20-year followup of the longest, ongoing study of the impact of childhood abuse on female development. This feasibility study will set the stage for a highly innovative, competitive R01 aimed at testing comprehensive geneXenvironment and bio- psycho-social models of risk and resilience throughout development and across generations for females abused in childhood and their families. PUBLIC HEALTH RELEVANCE: This is a feasibility study to locate and recontact families participating in a 20-year longitudinal study to ascertain demographic updates and willingness to participate in a 7th wave. A subset of families will undergo pilot testing of new technologies including the use of para-professionals for biological sampling (including genetic sampling) and remote web and PC-based assessment procedures for adult participants and their offspring. The study will set the stage for a highly innovative, competitive R01 aimed at testing complex multivariate psychosocial, genetic predisposition, gene-environment interaction, and biobehavioral models of risk and resilience throughout development and across generations for females abused in childhood and their families.