Age-related decline in sleep-dependent memory consolidation

睡眠的一个重要功能是允许巩固记忆。例如，在一种简单的、 在包含相对于12小时间隔的睡眠的12小时间隔之后，显式序列任务得到改进 睡不着觉。然而，睡眠的这种好处在老年人(45-80岁)中并不存在 赚钱的任务。相反，初步研究表明，依赖睡眠的记忆巩固可能 对于非运动性认知任务(词对联想学习)，老年人保持完好无损。这些结果 对将在拟议研究中审查的一些问题进行了讨论。首先，与年龄相关的 睡眠依赖记忆的下降序列学习任务的巩固反映了睡眠的变化 随着年龄增长的建筑？同样，空闲的睡眠对词对联想学习的益处是否反映了 某些睡眠阶段的稳定性？序列学习任务中与睡眠相关的性能变化包括 与NREM-2睡眠有关，而SWS似乎对巩固词对联想至关重要 学习。因此，记忆巩固和睡眠架构的关系，通过 多导睡眠监测，将在21-80岁的个人中进行评估。最后，不依赖于睡眠 运动学习的记忆巩固，在一年内发生的脱机性能变化 有一段时间是清醒的，老年人的睡眠也会减少吗？这个问题将用一系列的方式来回答 可将离线学习分离为基于睡眠的目标学习的学习范式 和不依赖睡眠的基于运动的学习

A critical function of sleep is to allow for memory consolidation. For example, performance on a simple, ixplicit sequence task is improved following a 12 hour interval containing sleep relative to a 12 hour interval without sleep. However, this benefit of sleep is not present in older adults (45-80 years) for sequence earning tasks. Conversely, preliminary research suggests that sleep-dependent memory consolidation may remain intact in older adults for a non-motor, cognitive task (word-pair association learning). These results ead to a number of questions which will be examined in the proposed research. First, does the age-related decline in sleep-dependent memory consolidation of sequence learning tasks reflect changes in sleep architecture with age? Likewise, does the spared sleep benefit on word-pair association learning reflect stability of certain sleep stages? Sleep-related changes in performance on the sequence learning task are associated with NREM-2 sleep while SWS seems to be critical for consolidation of word-pair association learning. Thus, the relationship of memory consolidation and sleep architecture, as measured by polysomnography, will be assessed in individuals ranging from 21-80 years of age. Finally, does sleepindependent memory consolidation of motor learning, off-line changes in performance occurring over a period of time spent awake, also decline in older adults? This question will be addressed with a sequence learning paradigm in which off-line learning can be dissociated into sleep-dependent goal-based learning and sleep-independent movement-based learning