The Use of Novel Technologies to Investigate Bone Health in Diabetes Mellitus

简介（由申请人提供）：阿玛斯博士花了相当多的时间来发展她的研究和职业生涯，通过完成临床内分泌学奖学金，成为美国内科委员会内分泌学，糖尿病和代谢认证，并完成，发表和发表临床研究项目。她的长期目标是成为一名在骨病领域进行临床转化研究的学术医师和科学家，并成为最先进的骨骼分析方法的专家。这个受指导的K奖包括一个生物统计学和流行病学方向的公共卫生硕士学位。它还侧重于骨研究领域所需的技术技能，包括经尿道骨活检程序，组织形态测量学，微计算机断层扫描（micro-CT）和外周定量计算机断层扫描（pQCT）的培训。克雷顿大学骨质疏松症研究中心是一个独特的地方，研究骨骼超过45年的临床研究经验。Robert R. Recker博士在骨骼领域的进一步研究中发挥了重要作用。在研究中心工作或隶属于该中心的数十人每天都在使用建立学术生涯所需的技能和知识。这个受指导的研究项目旨在利用统计设计和研究的技术技能和知识，并将其应用于糖尿病患者的骨病问题。这是一项前瞻性的病例对照研究，糖尿病受试者使用DXA，骨标志物，pQCT，组织形态测量和微ct经尿道骨活检。这项人体研究旨在阐明1型糖尿病对1)骨重塑的影响，包括骨形成和骨吸收的组织形态学和生化指标，以及2)对结构的影响，包括骨小梁的微结构排列和骨矿物质密度。

DESCRIPTION (provided by applicant): Dr. Armas has spent considerable time developing her research and professional career by completing a clinical endocrinology fellowship, becoming American Board of Internal Medicine certified in Endocrinology, Diabetes and Metabolism, and completing, presenting and publishing clinical research projects. Her long-term goals are to be an academic physician-scientist conducting clinical translational research in the field of bone disease and to be expert in state-of-the-art methods of bone analysis. This mentored K award includes a Masters of Public Health with a concentration in biostatistics and epidemiology. It is also focused on the technological skills needed in the bone research field, including training in transilial bone biopsy procedure, histomorphometry, micro-computed tomography (micro-CT), and peripheral quantitative computed tomography (pQCT). Creighton University Osteoporosis Research Center is a unique place to study bone with over 45 years of clinical research experience. Dr. Robert R. Recker has been instrumental in furthering research in the bone field. The skills and knowledge needed to build an academic career in research are being used every day by dozens of people in and affiliated with the research center. This mentored research project is designed to use the technological skills and knowledge of statistical design and research and apply them to the problem of bone disease in patients with diabetes. This is a prospective, case-control study of diabetic subjects using DXA, bone markers, pQCT, histomorphometry, and micro-CT of transilial bone biopsies. This human study is designed to elucidate the effect of Type 1 diabetes on 1) bone remodeling, including histomorphometric and biochemical measures of bone formation and resorption, and 2) on structure, including micro-architectural arrangement of trabeculae and bone mineral density.