Abramson Cancer Center Support Grant

描述（由申请人提供）：本申请，如果资助，将支持招聘，雇用，发展和保留一个新的独立科学家在宾夕法尼亚大学医学院的常设教师的终身教职轨道。这是Abramson癌症中心（ACC）肿瘤生物学计划（TBP），Abramson家庭癌症研究所（AFCRl）和癌症生物学系的联合招募工作。TBP由Anil Rustgi，MD和William Lee，MD，PhD领导，其具体目标是了解肿瘤的分子和细胞基础，以便为开发新的癌症诊断和治疗方法提供基础。AFCRl由塞莱斯特西蒙博士领导，致力于招募和支持杰出的外部研究人员，他们带来了癌症中心尚未提供的创新研究和技术。癌症生物学系由医学博士刘易斯·乔多什领导，致力于阐明人类癌症的分子、细胞和病理生理学基础的基本方面，包括肿瘤进展和对治疗的反应。ACC内的这三个小组长期以来一直致力于支持癌症研究科学家的招聘和职业发展。 本申请中提出的招募致力于血管生成和肿瘤微环境的基础和转化研究的科学家支持实体的三个科学优先事项：1）理解促进致癌和肿瘤进展的肿瘤微环境的关键方面; 2）理解血管生成和抗血管生成监视在癌症起始和进展中的作用;和3）鉴定预测癌症易感性和癌症结果的宿主基因-环境相互作用，并利用该信息开发用于预防和治疗癌症的靶向干预。

DESCRIPTION (Provided by the applicant): This application, if funded, will support the recruitment, hiring, development and retention of a newly independent scientist in the tenure track of the standing faculty of the University Of Pennsylvania School Of Medicine. This is a joint recruitment effort of the Tumor Biology Program (TBP) of the Abramson Cancer Center (ACC), the Abramson Family Cancer Research Institute (AFCRl), and the Department of Cancer Biology. The TBP is led by Anil Rustgi, MD and William Lee, MD, PhD and has the specific goal of understanding the molecular and cellular basis of neoplasia in order to provide a foundation for developing new diagnostic and therapeutic approaches to cancer. The AFCRl is led by Celeste Simon, PhD and is dedicated to the recruitment and support of outstanding external investigators who bring innovative research and technologies that are not already available at the Cancer Center. The Department of Cancer Biology, which is led by Lewis Chodosh, MD, PhD, is focused on elucidating fundamental aspects of the molecular, cellular, and pathophysiological basis of human cancers, including tumor progression and response to therapy. These three groups within the ACC have a long history of dedicated support to the recruitment and career development of scientists studying cancer. The recruitment of a scientist dedicated to the basic and translational research of angiogenesis and tumor microenvironment proposed in this application supports three of the scientific priorities of the entities: 1) to understand critical aspects of the tumor microenvironment that promote carcinogenesis and tumor progression; 2) to understand the role of angiogenesis and anti-angiogenic surveillance in cancer initiation and progression; and 3) to identify host gene-environment interactions that predict cancer susceptibility and cancer outcomes and utilize this information to develop targeted interventions for the prevention and treatment of cancer.