Mechanisms of plasticity and repair after SCI

这项修订后的PSO拨款的目标是扩大目前由cobr资助的肯塔基脊髓损伤研究中心（KSCIRC）在路易斯维尔大学（UofL）的核心设施。我们建议扩大这些核心在神经发育和中枢神经系统损伤方面的研究范围，2)将更多的pi引入中心，以加强他们的研究计划，并将他们的新技术和方法引入COBRE pi。我们将把涉及的pi从8个增加到22个。核心项目将促进NIH资助和非资助的初级和高级pi的研究项目，如果没有训练有素的核心人员，这些项目将不可能实现。每个核心将由资助的PI指导，并安置在独立的专用实验室空间中。所有pi都可以使用这些核心。我们将优先考虑初级和无资金的私人投资项目。UofL管理部门将为COBRE/KSCIRC核心设施提供重要的空间和财政承诺。

The goal of this revised PSO grant is to expand the present COBRE-funded Kentucky Spinal Cord Injury Research Center (KSCIRC) Core facilities at the University of Louisville (UofL). We propose to broaden the scope of research that these Cores support in neural development and CNS injury, and 2) bring additional PIs into the Center both to enhance their research programs and to bring their new techniques and approaches to the COBRE PIs. We will increase the number of involved PIs from 8 to 22. The Cores will facilitate the research programs of both NIH funded and non-funded junior and more senior PIs in directions that would not be possible without the highly trained Core personnel. Each Core will be directed by a funded PI and housed in independent, dedicated laboratory space. All PIs will have access to these Cores. We will give priority access to junior and unfunded PIs. The UofL administration will make significant space and financial commitment to the COBRE/KSCIRC Core Facilities. The Cores are: A) Administration and Biostatistics, B) Surgery and Animal Care, C) Behavioral and Electrophysiological Assessment, D) Cell and Tissue Imaging and Histology, and E) Human Translational Studies. The specific aims are: 1. Support and enhance the scope of the strong ongoing UofL NINDS and non-NINDS funded research in the areas of nervous system injury and repair, including our continuing development of innovative technology. 2. Make our technologies available to additional UofL neuroscientists working in other areas of nervous system development and repair to facilitate their individual research programs with novel approaches. 3. Facilitate the development of the research programs of junior and more senior unfunded Investigators. 4. Enhance collaborative opportunities between PIs that utilize these Core facilities.