COBRE: UVM: CORE D: TRANSLATIONAL NEUROSCIENCE TRAINING

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 科布雷中心最初的目标之一是创建一个翻译核心：(A)促进基础和临床神经科学家之间的互动，以加强翻译研究，以及(B)支持本科生、医学生和住院医生的研究体验。2003年，我们为本科生启动了一项深入的暑期研究体验，即暑期神经科学本科生研究奖学金计划。 翻译核心每年的一项主要职责是组织和提供一门讲授课程，重点是一种特定的神经疾病或精神疾病。本课程旨在说明转化性神经科学研究的进展，其重点是特定的疾病实体。承保的疾病每年都在变化。在以前的赠款期间，涵盖的疾病实体包括帕金森病、多发性硬化症、精神分裂症、肌萎缩侧索硬化症、脑血管疾病和自闭症。在过去的一年里，该课程的重点是老年人的痴呆症，包括从临床研究到基本分子方法的每周12次会议。神经学、心理学和精神病学系的教师在这门团队授课的课程中进行了合作。此外，两位外部演讲者，布拉德·海曼博士(哈佛大学)和约翰·莫里斯博士(华盛顿大学)在过去的一年里贡献了演讲。参加该课程的有研究生、住院医生和教职员工。 在过去的拨款期间，没有医学生选择通过翻译核心全年医学研究计划获得研究经验，尽管该计划的广告宣传得很好。明年，我们将继续努力，积极招收医科二年级学生，争取这个研究机会。 夏季本科生神经科学研究奖学金(SNURF)项目继续非常成功。自成立以来，每年都有8名学生参加这个暑期研究项目。我们已经能够吸引来自全国各地的学生，每年都包括年轻女性和代表人数不足的群体的学生。基础神经科学和临床神经科学教师都以学生导师的身份参与，不同神经科学教师之间的互动的一个副作用是加强了翻译研究活动。本科生进行为期10周的研究，阅读初级文献，并参加科布雷教职员工的讲座。 在刚刚过去的这个夏天，翻译核心为9名参加我们的暑期神经科学本科生奖学金项目的学生提供了津贴和住宿支持。匹配的支持来自教师的研究经费，以及解剖学和神经生物学系和神经病学系的运营资金。九名学生中有三名来自代表不足的少数族裔群体。在过去的一年里，我们还获得了补充资金(附录3P20 RR016435-09S1--参见子项目页面)来加强这个本科生研究计划。去年夏天，这笔补充资金让我们多资助了10名学生。我们将使用剩余的补充资金和Parent Cobre基金在即将到来的夏天支持这个项目中的17名学生。 在学生完成暑期研究项目后，我们继续定期与他们联系，以监督他们的职业发展和我们在帮助他们方面的有效性。在该项目存在的六年中，大多数过去的参与者都进入了医学院或研究生院，其中包括两名目前在我们的神经科学研究生项目学习的学生。其他人选择从学校休学，接受技术职位，其中两人在密歇根大学。 我们很高兴在这里获得的经验对我们过去的许多学生的专业发展有很大的帮助。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. One of the original goals of the COBRE Center was the creation of a Translational Core to: (a) facilitate interactions between basic and clinical neuroscientists to enhance translational research, and (b) support research experiences for undergraduate students, medical students and residents. In 2003, we initiated an in-depth summer research experience for undergraduate students, the Summer Neuroscience Undergraduate Research Fellowship Program. A major responsibility of the Translational Core each year is to organize and present a didactic course, which focuses on a specific neurological disease or psychiatric disease. The course is designed to illustrate the progress of translational neuroscience research, which is focused on a particular disease entity. The disease to be covered changes every year. In prior grant periods, the disease entities covered included Parkinson's Disease, Multiple Sclerosis, Schizophrenia, Amyotrophic Lateral Sclerosis, Cerebrovascular Diseases and Autism. This past year, the course focused on Dementia of the Elderly and consisted of 12 weekly sessions ranging from clinical research to basic molecular approaches. Faculty from the Departments of Neurology, Psychology, and Psychiatry collaborated in this team-taught course. In addition, two outside speakers, Drs. Brad Hyman (Harvard Uuniversity) and John Morris (Washington University) contributed lectures this past year. The course is attended by graduate students, residents and faculty. During this past grant period, no medical students elected to gain research experience through the Translational Core year-out medical research program even though the program was well advertised. We will continue efforts to actively recruit second year medical students for this research opportunity next grant year. The Summer Undergraduate Neuroscience Research Fellowship (SNURF) program continues to be very successful. Since its inception, 8 students have participated in this summer research program each year. We have been able to attract students from across the country and have included young women and students from underrepresented groups each year. Both basic and clinical neuroscience faculty participate as student mentors and a side effect of the interaction of different neuroscience faculty has been an enhancement of translational research activities. Undergraduates perform 10 weeks of research, read primary literature and attend lectures given by COBRE faculty. This past summer, the Translational Core provided stipend and lodging support for nine students participating in our Summer Neuroscience Undergraduate Fellowship program. Matching support was obtained from faculty research grants and through operating funds from the Departments of Anatomy & Neurobiology and Neurology. Three of the nine students were from underrepresented minority groups. This past year, we also received supplemental funding (Supplement 3P20 RR016435-09S1 -- see subproject page) to enhance this undergraduate research program. The supplemental funds allowed us to support an additional 10 students last summer. We will use the remaining supplemental funds and parent COBRE funds to support 17 students in this program this upcoming summer. We continue to contact students periodically after they graduate from the summer research program in order to monitor their career development and our effectiveness in assisting them. In the six years the program has been in existence, the majority of past participants have gone on to medical or graduate school, including two who are currently students in our Neuroscience Graduate Program. Others have elected to take time out from their schooling to accept technical positions, two at UVM. We are pleased that the experience gained here has significantly helped many of our past students in their professional development.