LEUKOCYTE-DERIVED BIOMARKERS AS PREDICTORS OF RISK AND PROGRESSION IN ALZHEIMER'

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的主要目标是确定认知或神经退行性疾病患者与健康成年人在血液中的基因及其产物模式是否有任何差异。遗传物质决定头发的颜色、眼睛的颜色和其他更复杂的特征。如果发现患有和不患有年龄相关认知障碍的人血细胞中遗传物质的水平和种类不同，就有可能利用这些差异来帮助诊断这些疾病。受试者将接受各种认知/记忆测试，并抽血。他们将被要求在3年内回来3-5次，再次抽血并完成记忆测试。这项研究将考察认知障碍患者和非认知障碍患者之间的基因模式差异。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The major goal of the study is to determine if there are any differences in the patterns of genes and their products in blood between people with cognitive or neurodegenerative disorders and healthy adults. Genetic material determines things such as hair color, eye color, and other more complex traits. If the level and kinds of genetic material in blood cells are found to differ between people with and without age-related cognitive disorders, it may be possible to use these differences to help diagnose these conditions. Subjects will be given a variety of cognitive/memory testing and will have their blood drawn. They will be asked to return 3-5 times over 3 years to have their blood drawn again and memory tests completed. The study will examine the differences in the gene patterns between people with cognitive impairment and those without.