Alzheimer's Disease Research Center

描述（由申请人提供）：华盛顿大学（UW）阿尔茨海默病研究中心（ADRC）的总体目标是继续提供一个研究环境，促进获得有关阿尔茨海默病和相关神经退行性痴呆疾病的病理生物学新知识，并将这些知识应用于实验治疗方法的开发。一个由基础和临床研究人员、卫生保健专业人员和行政人员组成的跨学科合作团队，支持并开展一系列富有成效的痴呆症研究和职业发展计划。尽管ADRC下属的研究将继续解决AD和其他痴呆疾病的遗传学问题，但ADRC的主题已重新集中在生物标志物和实验治疗上。ADRC通过直接合作和正式的多中心项目，如国家阿尔茨海默病协调中心（NACC）、阿尔茨海默病合作研究（ADCS）、综合的UW ADRC/俄勒冈健康与科学大学ADC神经病理学核心，以及NIA晚发性家族性阿尔茨海默病倡议，在更大的UW研究区和全国范围内支持ADRC内的生产性研究。一个职业发展环境，研究员和初级教师获得研究和临床技能是由一个富有成效的试点资助计划的支持。以前的成就已经为阿尔茨海默病的知识提供了基础、临床和行为方面的贡献。ADRC提出了5个ADRC核心和3个研究项目：项目1：药物诱导CNS胰岛素活性增加的CSF结合分析，Thomas J. Montine博士；项目二：鼻内胰岛素的治疗效果，Suzanne Craft博士；项目3：成人骨髓移植对体内A -肽积累和神经元损伤的调节，C. Dirk Keene博士。

DESCRIPTION (provided by applicant): The overall goal of the University of Washington (UW) Alzheimer's Disease Research Center (ADRC) is to continue to provide a research milieu that facilitates the acquisition of new knowledge about the pathobiology of AD and related neurodegenerative dementing disorders and applies this knowledge to the development of experimental therapeutics. An interdisciplinary collaborative team of basic and clinical investigators, health care professionals, and administrative personnel supports and carries out an array of productive dementia research and career development programs. Although ADRC affiliated research addressing the genetics of AD and other dementing disorders will continue, the ADRC theme has refocused on biomarkers and experimental therapeutics. The ADRC supports productive research within the ADRC, in the greater UW research community and nationally through direct collaborations and formal multi-center programs such as the National Alzheimer's Coordinating Center (NACC), the Alzheimer's Disease Cooperative Study (ADCS), the integrated UW ADRC/Oregon Health and Science University ADC Neuropathology Core, and the NIA genetics of late-onset familial AD initiative. A career development environment in which fellows and junior faculty acquire research and clinical skills is supported by a productive pilot grant program. Previous accomplishments have generated basic, clinical and behavioral contributions to knowledge about AD. The ADRC proposes five ADRC cores and three research projects: Project 1: CSF binding profiling of drug- induced increased CNS insulin activity, Dr. Thomas J. Montine; Project 2: Therapeutic Effects of Intra-Nasal Insulin Detemir, Dr. Suzanne Craft; Project 3: Modulation of A¿ peptide accumulation and neuron damage in vivo with adult bone marrow transplants, Dr. C. Dirk Keene.