OPTICAL FIBER PROBE FOR BIOMEDICAL RAMAN SPECTROSCOPY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们已经开发了一种光谱探针，它结合了漫反射，荧光和拉曼光谱三种光谱模式来诊断乳腺癌和动脉粥样硬化。组合探头通过输送和收集300-1000 nm光谱范围内的光，提供了从同一组织部位收集三种光谱模态的能力。该探头还允许将多个光源耦合到其单个激发光纤中，同时利用具有专门设计的光学涂层的激发和发射滤波器来抑制收集信号中的光纤背景。收集光纤被分开并重新定向到临床仪器的两个光谱仪/CCD模块，用于光谱分析和参数提取。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have developed a spectral probe that combines three spectroscopic modalities of diffuse reflectance, fluorescence and Raman spectroscopy to diagnose breast cancer and atherosclerosis. The combined probe provides capability of collecting the three spectroscopic modalities from the same tissue site, by delivering and collecting light in the 300-1000 nm spectral range. The probe also allows coupling of multiple sources into its single excitation fiber, while utilizing excitation and emission filters with specially designed optical coatings to suppress fiber background in the collected signal. Collection fibers is split up and redirected to two spectrograph/CCD modules of the clinical instrument for spectral analysis and parameter extraction.