LIPID METABOLITES AND PATHWAYS STRATEGY CONSORTIUM

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目得到了NIGMS Glue Grant的支持。整个计划有以下目标：（1）分离和检测特定细胞中的所有脂质，并发现和表征可能存在的任何新脂质。(2)定量存在的每种脂质代谢物，并定量细胞功能期间其水平和位置的变化。(3)定义每种脂质的生化途径，并开发定义相互作用网络的脂质图谱。为了帮助中性脂质核心，脂质组学重点领域，由R.C. Murphy，科罗拉多大学健康科学中心，BUSM MS资源协助确定新型中性脂质的结构。C. E.科斯特洛提供专业知识的新方法的质谱分析脂质的脂质地图计划，并出席年度会议的脂质地图调查。她将在2010年5月的脂质地图调查会议上发表特邀演讲。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project is supported by an NIGMS Glue Grant. The overall program has the following objectives: (1) Separate and detect all of the lipids in a specific cell and discover and characterize any novel lipids that may be present. (2) Quantitate each of the lipid metabolites present and quantitate the changes in their levels and location during cellular function. (3) Define the biochemical pathways for each lipid and develop lipid maps which define the interaction networks. To aid the Neutral Lipids Core, Lipidomics Focus Area, directed by R.C. Murphy, Univ. Colorado Health Sciences Center, the BUSM MS Resource assists in the structural determinations of novel neutral lipids. C. E. Costello provides expertise on new methods for mass spectral analysis of lipids to the Lipid MAPS program and attends the annual meeting of LipidMaps investigators. She will present an invited lecture at the may 2010 meeting of Lipid Maps investigators.