PSD-95 REGULATION OF DOPAMINE RECEPTOR SIGNALING

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 多巴胺受体集中在神经元的树突棘中，包括棘头和突触后密度，在那里它们被认为控制棘的兴奋性和突触性质。本项目的目标是研究介导调节多巴胺受体定位，运输和功能的PSD-95，脊髓内的原型突触支架蛋白的分子机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Dopamine receptors are concentrated in dendritic spines of neurons, including the spine head and the postsynaptic density, where they are thought to control the excitability and synaptic properties of spines. The goal of this project is to investigate the molecular mechanisms mediating the regulation of dopamine receptor localization, trafficking, and function by PSD-95, a prototypic synaptic scaffolding protein within spines.