ESTROGEN RECEPTOR-ALPHA CONTAINING NEURONS IN THE BRAINSTEM AND SPINAL CORD

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：测定雌激素受体α在去卵巢雌性猕猴脑干和脊髓中的分布规律，以了解雌激素在女性健康中的作用。 由于灵长类和啮齿类动物在性行为中对雌激素的依赖不同，所以灵长类动物脑干和脊髓中雌激素受体的分布模式也会有很大的不同。然而，到目前为止，关于灵长类动物的这一主题的信息很少。结果表明，与啮齿类动物脑干和脊髓中广泛分布的雌激素受体-α神经元不同，它们集中在恒河猴的副感觉、听觉和自主神经加工区域。雌激素处理对雌激素受体免疫反应神经元的分布模式无明显影响。因此，雌激素通过雌激素受体-α在灵长类动物的脑干和脊髓系统的功能中发挥的作用不大。此外，ER-a免疫反应神经元在灵长类动物、小鼠脑干和脊髓中的分布存在质和量上的差异，提示与啮齿动物相比，在灵长类动物中，ER-a在雌激素介导的行为控制中的作用较小。 这项研究使用了WNPRC动物服务中心。 对RR00167的补充资金在本报告所述期间之前结束；出版了一本出版物。 出版物： 雌性恒河猴脑干和脊髓中的雌激素受体-α免疫反应神经元：物种特有特征。神经科学158：798-810,2009。PMID：18996446

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To determine the distribution pattern of estrogen receptor-alpha in the brainstem and spinal cord of ovariectomized female monkeys to understand the role of estrogen in women's health. Because estrogen dependency in sexual behaviors differs in primates and rodents, the distribution pattern of estrogen receptors in the brainstem and spinal cord of primates would be quite different. However, to date there is little information on this topic in primates. The results suggest that in contrast to the presence of estrogen receptor-alpha containing neurons in a widespread area in the rodent brainstem and spinal cord, they are concentrated to regions involved in vicero-sensory, auditory, and autonomic processing in rhesus monkey. Estrogen treatment did not result in significant differences in the distribution pattern of estrogen receptor immunoreactive neurons. Therefore, estrogen action through estrogen receptor-alpha plays a modest role in function of the brainstem and spinal systems in primates. Moreover, there is qualitative and quantitative differences in the distribution of ER-a IR neurons in the primates and mice brainstem and spinal cord, suggesting that in primates ER-a plays a more modest role in control of estrogen-mediated behaviors as compared to rodents. This research used WNPRC Animal Services. Supplemental funding to RR00167 ended before this reporting period; a publication has resulted. PUBLICATION: Vanderhorst V.G., Terasawa, E., Ralston, H.J. 3rd Estrogen receptor-alpha immunoreactive neurons in the brainstem and spinal cord of the female rhesus monkey: Species-specific characteristics. Neuroscience 158: 798-810, 2009. PMID: 18996446