MOSAIC VACCINE-ELICITED IMMUNE RESPONSES IN RHESUS MONKEYS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 创造一种成功的艾滋病毒疫苗将需要开发一种免疫原，这种免疫原将产生足够广泛的细胞免疫，以应对病毒的极端遗传多样性。最近，有人建议，基于集中的艾滋病毒基因序列的疫苗可能为艾滋病毒流行毒株的遗传异质性带来的问题提供解决方案。共识和多价马赛克免疫原都是基于集中的基因序列。本研究旨在探索多价马赛克疫苗与普通免疫原疫苗所产生的CD4+和CD8+T淋巴细胞反应的广度。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Creation of a successful HIV vaccine will require development of an immunogen that will generate cellular immunity with sufficient cross-clade breadth to deal with the extreme genetic diversity of the virus. Recently it has been suggested that vaccines based on centralized HIV gene sequences might provide a solution to the problem posed by the genetic heterogeneity of the circulating strains of HIV. Both consensus and polyvalent mosaic immunogens are based on centralized gene sequences. The present study was designed to explore the breadth of CD4+ and CD8+ T lymphocyte responses generated by vaccination with polyvalent mosaic as compared to vaccination with consensus immunogens.