Biomedical Prevention

生物医学预防计划有来自16个部门和4所学校的41名研究人员，研究基地每年直接资助680万美元，其中包括来自NCI的440万美元。其成员在此期间发表了1092篇论文，其中37%是计划内合作，39%是跨计划合作。其中155篇发表在高影响力期刊上（影响因子> 7.51）。生物医学预防计划的目标是通过预防癌症的发生和提高早期诊断的生存率，降低癌症引起的发病率和死亡率。该计划的目标是：1）建立和支持以器官为中心的垂直整合研究项目，包括环境和遗传方法，以识别未来肿瘤进展的高风险个体和人群; 2）通过整合高通量基因组学，蛋白质组学和生物技术，发现和验证用于风险评估和早期检测常见高死亡率癌症的生物标志物; 3）识别和确定具有药理学和营养工具的干预措施的预防功效，目的是延迟或逆转被识别为高风险的个体的肿瘤进展;以及4）开发和验证新的生物统计学方法以研究群体聚类和替代终点。这些方案的目标人群包括一般人群和特殊高危群体。

The Biomedical Prevention Program has 41 investigators from 16 departments and four schools with a research base of $6.8 million in annual direct funding, Including $4.4 million from the NCI. Its members published 1092 papers over this grant period, of which 37% were intra-programmatic and 39% ware interprogrammatic collaborations. 155 of these publications were in high impact journals (Impact factor > 7.51). The objective of the Biomedical Prevention Program is to reduce the morbidity and mortality caused by cancer through preventing the occurrence and improving survival with earlier diagnosis. The alms of the program are: 1) To build and to support organ-focused, vertically Integrated research projects that encompass environmental and genetic approaches In order to Identify individuals and populations a high risk for future neoplastic progression; 2) To discover and validate biomarkers for risk assessment and early detection of common, high mortality cancers through the integration of high throughput genomic, proteomic, and biotechnologies; 3) To Identify and determine preventive efficacy of Interventions with pharmacologic and nutritional tools with the aim of delaying or reversing neoplastic progression in individuals identified at high risk; and 4) To develop and validate new biostatistical methodologies to study population clusters and surrogate endpoints. The populations targeted for these programs include the general population and special at-risk groups.