Cancer Biology

癌症生物学的基础研究对于揭开和理解癌症发生和发展的机制至关重要。从基础研究调查中获得的新见解对于产生癌症预防、诊断和治疗的新想法和新战略至关重要。癌症生物学计划(CB)的成员研究癌症生物学的基本细胞、分子、遗传、生化和免疫学机制，并开发调节它们的分子工具和实验疗法。该计划有31名积极参与的成员，他们来自夏威夷大学癌症中心、医学院、药学院以及女王医学中心。自上次审查以来，已有25人加入。目前，CB成员每年总共获得563万美元的直接资助，其中376万美元来自NCI，179万美元来自NIH的其他支持。在过去的五年里，他们总共撰写了193篇与癌症相关的出版物，其中21%来自方案内，12%来自方案间，5%来自方案间/方案内合作。 癌症研究中心的主要目标是通过多学科合作促进转化研究，通过对癌症发生和发展的细胞和分子机制的研究，确定新的治疗目标和癌症预防、早期发现、诊断、药物发现和治疗的潜在战略。该计划的主要目标是(1)对驱动肿瘤启动、进展和侵袭的过程产生新的机械学见解(癌症机制)；(2)利用细胞和生化分析(药物发现)以这些机制为靶标(新的小分子和天然产物)；(3)将这些结果转化为更有效的预防、早期发现和治疗方式(诊断和干预)。该计划的成员在细胞和分子生物学(信号转导、膜生物物理学、免疫生物学和炎症以及遗传学)、病毒学、化学生物学(生物化学、合成化学、天然产物)、病理学和外科方面拥有互补的专业知识。此外，该计划还包括致力于调查特定癌症的焦点小组。这些焦点小组提供了一个框架，将新的研究成果转化为针对这些癌症的有针对性的临床干预措施或创新的诊断方法。

Basic research in cancer biology is paramount to unraveling and understanding the mechanisms of cancer development and progression. Novel insights obtained from basic research investigations are critical for generating new ideas and strategies for cancer prevention, diagnosis and therapy. Members of the Cancer Biology Program (CB) investigate the fundamental cellular, molecular, genetic, biochemical, and immunological mechanisms of cancer biology and develop molecular tools and experimental therapeutics that modulate them. The program has 31 actively participating members from the University of Hawaii's Cancer Center, School of Medicine, and College of Pharmacy as well as the Queen's Medical Center. Of these 25 have joined since the previous review. CB members currently receive a combined $5.63M annually in direct funding, including $3.76M from the NCI and $1.79M in other NIH support. Over the past five years, they have authored a total of 193 cancer-related publications, of which 21% originated from intraprogrammatic, 12% from inter-programmatic, and 5% from inter/intra-programmatic collaborations. The primary goal of the CB is to foster translational research through multi-disciplinary collaborations where investigations of the cellular and molecular mechanisms of cancer development and progression lead to the identification of novel therapeutic targets and potential strategies for cancer prevention, early detection, diagnosis, drug discovery and treatment. The major goals of the program are (1) to generate novel mechanistic insight into the processes that drive tumor initiation, progression, and invasion (Cancer Mechanisms); (2) to target these mechanisms with new small molecules and natural products using cellular and biochemical assays (Drug Discovery); (3) to translate these results into more effective preventive, early detection, and therapeutic modalities (Diagnostics & Intervention). Members of the program have complementary expertise in cell and molecular biology (signal transduction, membrane biophysics, immunobiology and inflammation, and genetics), virology, chemical biology (biochemistry, synthetic chemistry, natural products), pathology and surgery. In addition, the program also includes focus groups dedicated to the investigation of specific cancers. These focus groups provide a framework to translate novel research findings into the development of targeted clinical interventions or innovative diagnostic approaches in these cancers.