Genetic Epidemiology and Biostatistics Core

遗传流行病学和生物统计学核心结合了Wake遗传分析的专业知识 森林大学医学院和亚拉巴马大学伯明翰分校。核心将继续 指导临床和遗传数据收集的实验设计。核心将继续提供 数据管理、统计和遗传数据分析方面的专门知识。遗传流行病学的目标 和生物统计学核心是（1）提供适当的实验设计，以解决特定的 遗传学和流行病学假设，（2）促进有效的数据收集程序， 数据分析，（3）使用连锁不平衡和关联方法细化易感区域，以及 (4)利用并在某些情况下开发分析SLE表型的新方法。 遗传流行病学和生物统计学核心的长期目标是利用遗传和 收集SLE患者及其家庭成员的流行病学数据，以确定遗传和 导致SLE易感性的流行病学危险因素。一个详细的计划，以确保核心 成功地实现了它的目标。

The Genetic Epidemiology and Biostatistics Core combines the expertise in genetic analysis of Wake Forest University School of Medicine and the University of Alabama at Birmingham. The Core will continue to guide the experimental design for collection of clinical and genetic data. The Core will continue to offer expertise in data management, statistical and genetic data analysis. The goals of the Genetic Epidemiology and Biostatistics Core are to (1) provide appropriate experimental designs tailored to address specific genetic and epidemiologic hypotheses, (2) facilitate efficient data collection procedures for preparation of data analysis, (3) refine regions of susceptibility using linkage disequilibrium and association methods, and (4) utilize and, in some cases, develop novel methods for analysis of SLE phenotypes. The long-term goals of the Genetic Epidemiology and Biostatistics Core are to utilize genetic and epidemiologic data collected on SLE patients and their family members in order to identify genetic and epidemiologic risk factors that contribute to the susceptibility for SLE. A detailed plan to assure that the Core is successful in meeting its objectives is described.