Parental Occupational Pesticide Exposure Assessment and Childhood Leukemia Risk

描述（由申请人提供）：父母职业性接触农药与儿童白血病风险增加的相关性不一致。大多数以前的研究都受到了限制，仅使用职称来估计农药暴露或缺乏足够的统计能力来检测关联。在这项提案中，我们将评估和量化暴露错误分类的影响，结果单独使用职称相比，详细的工作历史信息使用基于任务的工作模块，当确定儿童白血病的风险。我们将对来自北方加州儿童白血病研究（NCCLS）的数据进行二次分析，NCCLS是一项大型病例对照研究，超过40%的西班牙裔参与者和15%的参与父母有潜在的职业农药暴露。此外，NCCLS还包括对一部分参与者的家庭地毯灰尘中农药浓度的测量，这些测量将用于识别可能因父母职业暴露而污染家庭的农药。我们将确定农药浓度的可变性解释的职称相比，任务为基础的工作模块，并评估暴露测量误差。 公共卫生相关性：儿童白血病是最常见的儿童癌症，急性淋巴细胞白血病（ALL）是最常见的亚型。父母职业暴露于农药被怀疑是儿童白血病的一个重要危险因素，但研究结果并不一致，可能是由于错误分类错误。我们建议评估详细的任务为基础的工作模块是否提供更具体的估计暴露比职称单独，并量化的影响，父母职业暴露于农药和儿童急性淋巴细胞白血病的风险之间的关联的错误分类，以帮助通知其他研究父母职业农药暴露对儿童的各种健康结果的影响。

DESCRIPTION (provided by applicant): Parental occupational exposure to pesticides has been inconsistently associated with an increased risk of childhood leukemia. Most previous studies have been limited by the use of job titles alone to estimate pesticide exposure or lack of adequate statistical power to detect an association. In this proposal, we will evaluate and quantify the impact of exposure misclassification that results from using job titles alone compared to detailed job history information using task-based job modules, when determining the risk of childhood leukemia. We will conduct secondary analyses of data from the Northern California Childhood Leukemia Study (NCCLS), a large case-control study with more than 40% Hispanic participants and 15% of participating parents with potential occupational pesticide exposure. In addition, the NCCLS includes measurement of concentrations of pesticides in home carpet dust for a subset of participants that will be used to identify agricultural pesticides with potential for contamination of the home from parental occupational exposure. We will determine the variability of pesticide concentrations explained by job titles compared to task-based job modules, and assess exposure measurement error. PUBLIC HEALTH RELEVANCE: Childhood leukemia is the most common childhood cancer and acute lymphocytic leukemia (ALL) is the most frequent subtype. Parental occupational exposure to pesticides is suspected to be an important risk factor for childhood leukemia, but study findings have been inconsistent, likely due to misclassification errors. We propose to evaluate whether detailed task-based job modules provide more specific estimates of exposure than job titles alone, and to quantify the impact of misclassification on the associations between parental occupational exposure to pesticides and risk of childhood ALL, in order to help inform other studies examining the effect of parental occupational pesticide exposure on various health outcomes in children.