NHLBI Research Center at Howard University

这项提议的目的是在霍华德大学建立NHLBI研究中心，以增强和加强与心、肺、血液以及睡眠疾病和紊乱相关的生物医学和行为研究的研究能力和资源。该中心的重点将是血红蛋白疾病、铁代谢和氧气感应，它将建立在我们现有的NHLBI研究科学家计划的基础上并与之协同。从1999年到2010年，霍华德大学的NHLBI研究科学家奖帮助组织了一项新的研究计划，帮助获得了34项额外的资助，总直接成本超过2900万美元，总间接成本超过900万美元。该项目为霍华德大学带来了11名新的研究人员。还为22名本科生、14名医学生、7名硕士研究生、8名博士后、10名博士后、19名住院医师和研究员以及22名现有教职员工提供了研究机会。在对少数群体造成不成比例影响的各种疾病方面取得了进展，包括严重疟疾贫血、非高铁血铁超载、潜在的血液学状况对艾滋病毒疾病的影响以及镰状细胞病的肺部并发症。该奖项产生了150份同行评议的出版物。在这一成功的基础上，我们现在提议在霍华德大学建立NHLBI研究中心。 目标1.建立一个由六名外部科学家组成的外部顾问委员会，他们将为拟议中的霍华德大学领导力卫生与生命科学研究中心提供建议，并对研究计划进行评估。 目标2.招聘一名额外的资深科学家，他可以补充和加强我们在血球疾病、铁代谢和氧气感应方面的现有研究计划。 目的3.扩大和加强霍华德大学现有的NHLBI研究科学家计划在非裔美国人和其他人群中镰状细胞疾病的临床和分子方面、铁代谢和氧气感觉方面的研究进展。

The purpose of this proposal to establish an NHLBI Research Center at Howard University that will augment and Strengthen research capabilities and resources in biomedical and behavioral research related to heart, lung and blood, and sleep diseases and disorders. The focus of the Center will be hemoglobinopathies, iron metabolism and oxygen-sensing, and It will build on and synergize with our existing NHLBI Research Scientist Program. From 1999 to 2010, the NHLBI Research Scientist Award at Howard University has facilitated the organization of a new research program that has contributed to the acquisition of 34 additional grants with total direct costs of over $29,000,000 and total Indirect costs of over $9,000,000. The program has been instrumental in bringing 11 new research faculty to Howard University. It has also provided research opportunities for 22 undergraduate students, 14 medical students, 7 masters level graduate students, 8 PhD candidates, 10 post-doctoral candidates, 19 residents and fellows, and 22 existing faculty members. Progress has been made in a variety of diseases that disproportionately affect minority populations, including severe malarial anemia, non-HFE iron overload, the influence of underlying hematologic conditions on HIV disease, and the pulmonary complications of sickle cell disease. The Award has resulted in 150 peer-reviewed publications. Building on this success, we now propose to establish an NHLBI Research Center at Howard University. Aim 1. Establish an External Advisory Board of six external scientists who will advise the proposed NHLBI Research Center at Howard University leadership and provide an evaluation of the research program. Aim 2. Recruit an additional established scientist who can complement and build upon our existing research program in hemglobinopathies, iron metabolism and oxygen sensing. Aim 3. Expand and enhance the research advances made by the existing NHLBI Research Scientist Program at Howard University in clinical and molecular aspects of sickle cell disease, iron metabolism and oxygen sensing in African-Americans and other populations.