Mentoring Research Excellence in Aging and Regenerative Medicine

描述（由申请人提供）：本COBRE应用程序的目标是发展有前途的初级研究人员在生物医学老化研究的职业生涯，并建立在这一领域的计划实力。职业发展将利用一个强大的核心研究导师谁将提供职业发展的建议，以及科学发展和实验室管理健全的实用建议。这个COBRE中的五个项目侧重于几个互补的主题，这些主题有助于我们对衰老的理解，从基本的遗传和表观遗传贡献到心血管和神经认知机制。其中三个项目以人类衰老为特征，一个侧重于啮齿动物模型，一个利用培养细胞。所有项目都具有高度的翻译相关性。任命了一个由经验丰富的科学家/行政人员组成的内部咨询委员会。COBRE领导层由COBRE的导师和核心高级研究人员组成，他们坚定地致力于该计划;这些科学家拥有出色的研究和指导记录。此外，一个杰出的外部顾问委员会将参与指导和评估初级研究人员和COBRE计划本身的进展。职业发展将涉及一系列的计划会议，接触教学补助金写作会议，和研讨会，以开发一个高度协作的环境，为初级教师，以及杜兰老龄中心的其他成员。COBRE还为我们的科学家提供了生物统计学和基因组学研究核心设施，使他们能够进行新的实验，并加强实验设计和数据分析。杜兰老龄化中心为涉及杜兰大学八所学校的老龄化研究提供了一个杰出的跨学科环境。该中心的发展和壮大拥有强大的制度支持。这个COBRE将代表杜兰老龄化中心的核心，它将为我们在路易斯安那州建立一个特殊的生物医学老龄化研究企业做出巨大贡献。

DESCRIPTION (provided by applicant): The objective of this COBRE application is to develop the careers of promising junior investigators in biomedical aging research and to build programmatic strength in this area. Career development will utilize a strong core of research mentors who will provide career development advice as well as sound practical advice on scientific development and laboratory management. The five projects in this COBRE focus on several complementary themes that contribute to our understanding of aging, from basic genetic and epigenetic contributions through cardiovascular and neurocognitive mechanisms. Three of the projects feature human aging, one focuses on rodent models, and one utilizes cultured cells. All of the projects have a high translational relevance. An internal advisory committee consisting of seasoned scientist/administrators has been appointed. The COBRE leadership is composed of mentors and core senior investigators for this COBRE, and they are strongly committed to the program; these scientists have outstanding research and mentoring records. In addition, a prominent board of external advisors with outstanding research careers and track records of career development for junior scientists will participate in both the guidance and evaluation of the progress of the junior investigators and of the COBRE program itself. Career development will involve a series of program meetings, exposure to didactic grant-writing sessions, and seminars to develop a highly collaborative environment for both the junior faculty, as well as other members of the Tulane Center for Aging. The COBRE also provides a Biostatistics and Genomics Research Core facility for our scientists to make new experimental possibilities available to them and to enhance experimental design and data analysis. The Tulane Center for Aging provides an outstanding interdisciplinary environment for aging research involving eight of the schools at Tulane University. The Center enjoys strong institutional support for its development and growth. This COBRE will represent the centerpiece of the Tulane Center for Aging, and it will contribute strongly to our building of an exceptional biomedical aging research enterprise in Louisiana.