Mentoring Research Excellence in Aging and Regenerative Medicine

指导衰老和再生医学领域的卓越研究

• 批准号: 10851107
• 负责人: S MICHAL JAZWINSKI
• 金额: $ 105.48万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10851107
• 关键词: Address; Administrative Supplement; Affect; Aging; Amputation; Anti-Inflammatory Agents; Apoptosis; Apoptotic; Applications Grants; Architecture; Area; Bioinformatics; Biological Aging; Cell Communication; Cell physiology; Cells; Cementation; Centers of Research Excellence; Cessation of life; Chronic; Chronic Disease; Cicatrix; Coculture Techniques; Collaborations; Collagen; Communities; Data; Data Set; Degenerative Disorder; Deposition; Digit structure; Disease; Distal; Elements; Environment; Extracellular Matrix; Extramural Activities; Faculty; Feedback; Fibroblasts; Fibrosis; Funding; Genomics; Goals; Growth; Homeostasis; Impairment; Inflammation; Inflammatory; Infrastructure; Injury; Interdisciplinary Study; Intervention; Kidney; Knowledge; Liver; Lung; Macrophage; Measures; Mentors; Molecular; Morbidity - disease rate; Morphology; Mus; Musculoskeletal; Myofibroblast; NADPH Oxidase; Natural regeneration; Organ; Pathologic; Pathology; Pathway interactions; Pharmaceutical Preparations; Phenotype; Pilot Projects; Play; Positioning Attribute; Process; Production; Public Health; Publishing; Pulmonary Fibrosis; Reactive Oxygen Species; Regenerative Medicine; Regenerative research; Research; Research Personnel; Resistance; Risk Factors; Role; Services; Signal Transduction; Source; Specimen; Talents; Testing; Therapeutic Intervention; Time; Tissues; Transforming Growth Factor beta; United States; Update; body system; callous unemotional trait; career development; cell type; comparative; comparison control; digit regeneration; effective therapy; genotoxicity; healing; in vivo; inhibitor; lung injury; lung repair; mortality; multiple omics; paracrine; profibrotic cytokine; programs; repaired; senescence; soft tissue; success; sustainable resource; therapeutic development; tissue culture; tissue regeneration; tissue repair; transcriptomics; virtual; wound healing

Aging is a process that is the major risk factor for chronic disease and degeneration. However, it is beginning to be appreciated that disease and degeneration impinge on biological aging, in something akin to a feedback loop, suggesting that a better knowledge of one contributes to an understanding of the other. This necessitates that development of therapeutic interventions must address the degenerative disorders of aging, while the search for broad interventions that target the biological aging process itself continues. This agenda calls for the creation and nurturing of an environment in which multidisciplinary research of sufficient breadth is focused on key elements of aging and regeneration. At the same time, it is necessary to populate this translational space with talented and successful investigators. The project goals are to: (1) Continue to expand the number of aging and regeneration research-oriented, funded investigators within the scientific community at Tulane through pilot projects, with emphasis on collaborative research, and to provide a mentoring program for these researchers and others that supports successful career development. (2) Maintain the state-of-the-art infrastructure to provide sustainable resources that continuously enhance the competitiveness of center faculty for national funding, by expanding and updating the services performed by our Genomics, Bioinformatics, and Spatial Multiomics Core. (3) Cement the position of the Tulane Center for Aging at the forefront of aging and regenerative medicine by growth of its thematic, multidisciplinary research foci to facilitate successful extramurally funded collaborations that will support and sustain the center. The COBRE project leaders have coalesced into four research foci, one of which is Musculoskeletal and Soft Tissue Adaptation and Homeostasis. It is this area that is targeted for this administrative supplement. Extrinsic and intrinsic damage to body organs is constantly a threat to homeostasis during aging. Bodies can repair such damage rather well if it is not too severe. In fact, there are a few examples of near perfect repair that we can call regeneration, such as the regeneration of the digit tip. However, if the damage is extensive or chronic, the result is pathological healing that leaves behind a fibrotic scar compromising organ function. Virtually all organs are capable of repair and renewal and are prone to this pathology to a lesser or greater extent. The premise is that there are similarities, at the molecular and cellular levels, in fibrosis in these various organ systems, in addition to the differences, that can illuminate the factors that contribute to regeneration rather than fibrosis. These factors may best be uncovered using a comparative approach in several organ systems. To best leverage this approach, a team of experts in repair, regeneration, and fibrosis, in several different organs will be assembled, starting with the amputated digit tip and the damaged lung, along with experts in bioinformatics to facilitate unraveling its complexity in these organ systems. Their singular goal is to elucidate fibrosis – repair gone wrong. Fibroproliferative disorders account for 45% of the deaths in the United States, thus this research has significant public health impact.

衰老是一个过程，是慢性疾病和变性的主要危险因素。然而，它正在开始改变