Mentoring Research Excellence in Aging and Regenerative Medicine

指导衰老和再生医学领域的卓越研究

• 批准号: 10414530
• 负责人: S MICHAL JAZWINSKI
• 金额: $ 114万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10414530
• 关键词: Address; Adopted; Aging; Area; Bioinformatics; Biological Aging; Biological Process; Biomedical Research; Cell Proliferation; Centers of Research Excellence; Chronic Disease; Clinical; Collaborations; Communities; Core Facility; Degenerative Disorder; Development; Disease; Educational workshop; Elements; Environment; Extramural Activities; Faculty; Feedback; Foundations; Funding; Genome Stability; Genomics; Goals; Grant; Growth; Health; Homeostasis; Immunity; Inflammaging; Inflammation; Infrastructure; Institution; Interdisciplinary Study; Intervention; Knowledge; Life; Life Expectancy; Longevity; Maintenance; Measures; Mentors; Metabolic; Musculoskeletal; Natural regeneration; Neurocognitive; Pathogenesis; Phase; Physical Function; Pilot Projects; Positioning Attribute; Preventive; Process; Program Development; Public Health; Quality of life; Regenerative Medicine; Regenerative research; Regulation; Research; Research Infrastructure; Research Personnel; Research Training; Retirement; Risk Factors; Seeds; Services; Talents; Therapeutic Intervention; Time; Training; Training Programs; Twin Multiple Birth; Universities; Update; aging population; baby boomer; base; career development; cognitive function; cohort; design; expectation; improved; interest; medical schools; molecular imaging; multidisciplinary; neuroinflammation; programs; psychosocial; soft tissue; stem cell function; success; sustainable resource; therapeutic development; wound healing

Aging is a biological process that is the major risk factor for chronic disease and degeneration during the lifespan. However, it is beginning to be appreciated that disease and degeneration impinge on the aging process, in something akin to a feedback loop, suggesting that a better knowledge of one contributes to an understanding of the other. This necessitates that development of therapeutic interventions must address the degenerative disorders of aging, while the search for broad interventions that target the biological aging process itself continues. The agenda just described calls for the creation and nurturing of an environment in which multidisciplinary research of sufficient breadth is focused on key elements of aging and regeneration. At the same time, it is necessary to populate this translational space with talented and successful investigators. Our Phase I and II COBRE launched and further propelled us in this direction by allowing us to seed several key research topics with ambitious junior investigators, who in just nine years have advanced to independently funded status with remarkable success. Our task is not yet done, however, if we are to maintain momentum and a critical mass of investigators dedicated to aging and regenerative medicine. COBRE Phase III will allow us to continue to grow our cadre of dedicated investigators through our pilot projects and by enriching the research environment through our mentoring and training programs, as well as topical seminars. These efforts will be aided by the maintenance of a state-of-the-art Genomics, Bioinformatics, and Molecular Imaging Core that has a sustaining revenue base. Our emphasis is on multiplying the opportunities for interactions that will generate collaborative projects that are synergistic and competitive for multicomponent project grant funding. Our goals are to: (1) Continue to expand the number of aging and regeneration research-oriented, funded investigators within our scientific community through our pilot projects, with emphasis on collaborative research, and to provide a mentoring program for these researchers and others that supports successful career development. (2) Maintain our state-of-the-art infrastructure to provide sustainable resources that continuously enhance the competitiveness of our faculty for national funding, by expanding and updating the services performed by our Genomics, Bioinformatics, and Molecular Imaging Core. (3) Cement the position of the Tulane Center for Aging at the forefront of aging and regenerative medicine by growth of our thematic, multidisciplinary research foci to facilitate successful extramurally funded collaborations that will support and sustain the center. This effort will be supported by our research workshops, training and career development programs, and seminars.

衰老是一种生物学过程，是慢性疾病和退行性疾病的主要危险因素。 寿命。然而，人们开始认识到，疾病和退化对衰老的影响 过程，在类似于反馈循环的东西中，表明对一个人的更好的了解有助于 对他人的理解。这就要求治疗干预措施的发展必须解决 衰老的退行性疾病，同时寻找针对生物衰老的广泛干预措施 这一过程本身仍在继续。刚才描述的议程呼吁创造和培育一个 有足够广度的多学科研究集中在老化和再生的关键因素上。在… 与此同时，有必要用有才华和成功的调查人员来填充这个翻译空间。 我们的第一阶段和第二阶段Cobre启动并进一步推动我们朝着这个方向前进，允许我们在几个 与雄心勃勃的初级调查人员一起进行关键研究课题，他们在短短九年内就独立完成了 获得资金支持，成绩斐然。然而，如果我们要保持势头，我们的任务还没有完成。 以及致力于衰老和再生医学的大量研究人员。科布雷三期将允许 我们将继续通过我们的试点项目和丰富 通过我们的指导和培训计划，以及专题研讨会，创造研究环境。这些努力 将通过维护最先进的基因组学、生物信息学和分子成像核心来提供帮助 这有一个可持续的收入基础。我们的重点是增加互动的机会， 为多组成部分的项目赠款资金提供具有协同性和竞争性的协作项目。 我们的目标是：(1)继续扩大老龄化与再生研究的数量，为其提供资金 通过我们的试点项目，我们科学界内的研究人员，重点是协作 研究，并为这些研究人员和其他人提供指导计划，支持成功 职业发展。(2)维护我们最先进的基础设施，以提供可持续的资源 不断增强我们教员在国家资助方面的竞争力，通过扩大和更新 由我们的基因组学、生物信息学和分子成像核心提供的服务。(三)巩固……地位 杜兰老龄中心处于老龄化和再生医学的前沿， 专注于多学科研究，以促进成功的外部资助合作，这将支持和 保持中心位置。这一努力将得到我们的研究研讨会、培训和职业发展的支持 课程和研讨会。