Enhancing the Impact of the COBRE in Aging and Regenerative Medicine at Tulane

增强 COBRE 在杜兰大学衰老和再生医学领域的影响

• 批准号: 10792387
• 负责人: S MICHAL JAZWINSKI
• 金额: $ 30万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10792387
• 关键词: Address; Adopted; Aging; Area; Bioinformatics; Biological Aging; Biological Process; Biomedical Research; Cell Proliferation; Cementation; Centers of Research Excellence; Chronic Disease; Clinical; Collaborations; Communities; Core Facility; Dedications; Degenerative Disorder; Development; Disease; Educational workshop; Elements; Environment; Extramural Activities; Faculty; Feedback; Foundations; Funding; Genome Stability; Genomics; Goals; Grant; Growth; Health; Homeostasis; Immunity; Inflammaging; Inflammation; Infrastructure; Institution; Interdisciplinary Study; Intervention; Knowledge; Life; Life Expectancy; Longevity; Maintenance; Measures; Mentors; Metabolic; Musculoskeletal; Natural regeneration; Neurocognitive; Pathogenesis; Phase; Physical Function; Pilot Projects; Positioning Attribute; Preventive; Process; Program Description; Program Development; Public Health; Quality of life; Regenerative Medicine; Regenerative research; Regulation; Research; Research Infrastructure; Research Personnel; Retirement; Risk Factors; Services; Talents; Therapeutic Intervention; Time; Training; Training Programs; Twin Multiple Birth; Universities; Update; aging population; aspirate; baby boomer; base; career development; cognitive function; cohort; design; expectation; improved; interest; medical schools; molecular imaging; multidisciplinary; neuroinflammation; programs; psychosocial; soft tissue; stem cell function; success; sustainable resource; therapeutic development; wound healing

Aging is a biological process that is the major risk factor for chronic disease and degeneration during the lifespan. However, it is beginning to be appreciated that disease and degeneration impinge on the aging process, in something akin to a feedback loop, suggesting that a better knowledge of one contributes to an understanding of the other. This necessitates that development of therapeutic interventions must address the degenerative disorders of aging, while the search for broad interventions that target the biological aging process itself continues. The agenda just described calls for the creation and nurturing of an environment in which multidisciplinary research of sufficient breadth is focused on key elements of aging and regeneration. At the same time, it is necessary to populate this translational space with talented and successful investigators. Our Phase I and II COBRE launched and further propelled us in this direction by allowing us to seed several key research topics with ambitious junior investigators, who in just nine years have advanced to independently funded status with remarkable success. Our task is not yet done, however, if we are to maintain momentum and a critical mass of investigators dedicated to aging and regenerative medicine. COBRE Phase III will allow us to continue to grow our cadre of dedicated investigators through our pilot projects and by enriching the research environment through our mentoring and training programs, as well as topical seminars. These efforts will be aided by the maintenance of a state-of-the-art Genomics, Bioinformatics, and Molecular Imaging Core that has a sustaining revenue base. Our emphasis is on multiplying the opportunities for interactions that will generate collaborative projects that are synergistic and competitive for multicomponent project grant funding. Our goals are to: (1) Continue to expand the number of aging and regeneration research-oriented, funded investigators within our scientific community through our pilot projects, with emphasis on collaborative research, and to provide a mentoring program for these researchers and others that supports successful career development. (2) Maintain our state-of-the-art infrastructure to provide sustainable resources that continuously enhance the competitiveness of our faculty for national funding, by expanding and updating the services performed by our Genomics, Bioinformatics, and Molecular Imaging Core. (3) Cement the position of the Tulane Center for Aging at the forefront of aging and regenerative medicine by growth of our thematic, multidisciplinary research foci to facilitate successful extramurally funded collaborations that will support and sustain the center. This effort will be supported by our research workshops, training and career development programs, and seminars.

衰老是一个生物学过程，它是衰老过程中慢性疾病和退化的主要危险因素。 寿命然而，人们开始认识到，疾病和退化对衰老的影响， 这一过程类似于一个反馈循环，表明对一个人的更好了解有助于一个人的健康。 理解对方。这就要求治疗干预措施的发展必须解决 衰老的退行性疾病，而寻找针对生物衰老的广泛干预措施， 过程本身仍在继续。刚才所述的议程要求创造和培育一种环境， 该领域的多学科研究集中在衰老和再生的关键因素上。在 与此同时，有必要为这一翻译空间配备有才华和成功的调查人员。 我们的第一阶段和第二阶段COBRE启动，并进一步推动我们在这个方向上，让我们种子几个 与雄心勃勃的初级研究人员一起研究关键的研究课题，他们在短短九年内就独立地 取得了显著的成功。然而，如果我们要保持势头， 以及大量致力于衰老和再生医学的研究人员。COBRE第三阶段将允许 我们将继续通过试点项目和丰富 通过我们的指导和培训计划，以及专题研讨会的研究环境。这些努力 将得到最先进的基因组学、生物信息学和分子成像核心的支持 有持续收入基础的公司我们的重点是增加互动的机会， 产生协同作用和竞争力的多组分项目赠款资金的合作项目。 我们的目标是：（1）继续扩大衰老与再生研究的数量，资助 通过我们的试点项目，我们的科学界的研究人员，重点是合作 研究，并为这些研究人员和其他支持成功的人提供指导计划， 职业发展。(2)维护我们最先进的基础设施，以提供可持续的资源， 不断提高我们的教师对国家资金的竞争力，通过扩大和更新 由我们的基因组学、生物信息学和分子成像核心执行的服务。(3)巩固…的地位 杜兰中心老龄化的前沿老化和再生医学的增长，我们的主题， 多学科研究重点，以促进成功的校外资助的合作，将支持和 支持中心。我们的研究讲习班、培训和职业发展将支持这一努力 方案和研讨会。