Core Center for Chemical Senses

莫内尔化学传感中心成立于1968年，是世界上第一个也是唯一一个致力于化学传感基础研究的多学科研究所，并在NIDCD任务区内进行广泛的研究。莫内尔的两个最大的优势是运用广泛的方法来解决化学感官上的问题，以及莫内尔中心培养的有效的跨学科合作。在这份P30拨款申请中，提出了四个具有与化学感官高度相关的不同技术专长领域的研究核心：1.组织学，2.基因分型，3.分子生物学，4.表型。此外，一个行政核心将支持研究核心的任务，即在我们在NIDCD任务区的13个R01赠款的研究基地加强用户的研究。黄立全博士将领导组织学核心，以他在味觉感受器细胞中蛋白质可视化方面的专业知识为基础。基因分型核心将由丹妮尔·里德博士领导，他在基因分型和基因图谱方面有20多年的培训和经验。贝德里希·莫辛格博士是分子生物学和构建转基因小鼠模型方面的专家，是分子生物学核心的主任。亚历山大·巴赫马诺夫博士将负责表型核心研究；他以对小鼠和大鼠与化学感官相关的特征进行表型的能力而闻名。行政核心的主任是罗伯特·马戈尔斯基博士，他凭借在所有四个研究核心的研究领域的专业知识和行政经验，是唯一有资格担任这一核心中心赠款的私人投资者。这些核心将共同服务于莫内尔的研究基地，并通过促进化学感官的创新研究，进一步履行NIDCD了解味道、气味和普通化学感官的使命，以改善人类的健康和福祉。

The Monell Chemical Senses Center, founded in 1968, is the world's first and only multidisciplinary institute devoted entirely to basic research in the chemical senses and produces extensive research within the NIDCD mission area. Two of Monell's greatest strengths are the breadth of approaches brought to bear on problems in the chemical senses, and the effective interdisciplinary collaborations that are fostered at the Monell Center. In this P30 grant application for a Core Center in the chemical senses, four Research Cores with distinct areas of technical expertise highly relevant to the chemical senses are proposed: 1. Histology, 2. Genotyping, 3. Molecular Biology, and 4. Phenotyping. In addition, an Administrative Core will support the Research Cores in their mission to enhance the research of users in our Research Base of thirteen R01 grants in the NIDCD mission area. Dr. Liquan Huang will lead the Histology Core, building on his expertise in the visualization of proteins in taste receptor cells. The Genotyping Core will be led by Dr. Danielle Reed, who has over twenty years of training and experience with genotyping and gene mapping. Dr. Bedrich Mosinger, an expert in molecular biology and in constructing transgenic mouse models, is the Director of the Molecular Biology Core. Dr. Alexander Bachmanov will run the Phenotyping Core; he is well-known for his ability to phenotype mice and rats for traits relevant to the chemical senses. The Director of the Administrative Core is Dr. Robert Margolskee, who through his expertise in the research areas of all four Research Cores and his administrative experience is uniquely qualified to serve as PI of this Core Center grant. Together these Cores will serve the Research Base at Monell and by contributing to innovative research in the chemical senses further the mission of NIDCD to understand taste, smell and the common chemical sense in order to improve human health and well-being.