Physiology of Mind-Body Therapies: Meditative Breathing and Autonomic Adaptations

苏珊娜·M Bertisch，医学博士，公共卫生硕士，是一名普通内科医师，在临床研究中接受过培训， 对身心疗法的长期兴趣她的长期目标是发展一项独立的研究 研究冥想技术的生理效应，并开发有针对性的循证医学。 心血管风险增加人群的身心疗法。她的近期目标是 自主心血管生理学和身心临床试验方法学的知识和技能。博士 Bertisch提出的职业发展计划包括：1）获取实验室测量和数据 心肺生理学的分析技能; 2）获得身心医学行为的经验 临床试验; 3）通过正式的临床试验提高她的生理学，生物统计学和研究设计知识 教学法;和4）与她的导师和专家合作团队定期互动。该提案包括 这两个项目的重点是表征身心缓慢呼吸的急性和长期影响 （MBSB）自主活动。尽管有几个小组作出了努力，但关于急性 MBSB对交感神经活动和自主神经张力持续性适应的影响 重复MBSB的做法。候选人计划：1）比较不同的心血管和 MBSB在长期身心从业者和非从业者中的自主效应 横断面研究; 2）评估进行12周随机对照试验的可行性 测量MBSB对肥胖非从业者的自主活动和血压的影响 和高血压;并为未来更明确的研究获得初步数据。这两个项目将在 是最早使用现代测量和分析技术的国家之一，包括直接测量 交感神经活动完成拟议的研究和培训计划将提高博士。 能够进行以病人为导向的身心研究，进一步了解自主神经 心血管生理学，并允许她实现她的职业目标，成为一个独立的临床 研究身心疗法的生理机制和临床应用的研究者。 相关性（参见说明）： 该研究结果将为今后的临床和机制研究提供重要信息。 身心疗法，特别是在心血管疾病人群中，如高血压。更好的 了解身心呼吸练习的临床益处和机制将有助于 发展有针对性的身心治疗，以降低血压。

Suzanne M. Bertisch, MD, MPH,is a general internist fellowship-trained in clinical research, who possesses a long-standing interest in mind-body therapies. Her long-term goal is to develop an independent research career studying the physiological effects of meditative techniques and developing targeted evidence-based mind-body therapies in populations with increased cardiovascular risk. Her immediate goal is to acquire knowledge and skills in autonomic cardiovascular physiology and mind-body clinical trial methodology. Dr. Bertisch's proposed career development plan includes: 1) acquiring laboratory measurement and data analytic skills in cardiopulmonary physiology; 2) gaining experience in the conduct of mind-body medicine clinical trials; 3) improving her knowledge of physiology, biostatistics, and study design through formal didactics; and 4) regular interaction with her mentors and expert collaborative team. This proposal includes two projects that focus on characterizing the acute and long-term effects of mind-body slow breathing (MBSB) upon autonomic activity. Despite efforts by several groups, much remains unknown about the acute effects of MBSB on sympathetic activity and the sustained adaptations in autonomic tone evoked by repetitive practice of MBSB. The candidate plans to: 1) compare the differential cardiovascular and autonomic effects of MBSB among long-term mind-body practitioners and non-practitioners in an acute cross-sectional study; 2) evaluate the feasibility of conducting a 12-week randomized controlled trial measuring the effects of MBSB upon autonomic activity and blood pressure in non-practitioners with obesity and high blood pressure; and obtain preliminary data for future more definitive studies. Both projects will be among the first to use modern measurement and analytic techniques, including a direct measure of sympathetic nerve activity. Completion of the proposed research and training plan will enhance Dr. Bertisch's ability to conduct patient-oriented mind-body research, further her understanding of autonomic cardiovascular physiology, and allow her to achieve her career goal of becoming an independent clinical researcher investigating the physiological mechanisms and clinical applications of mind-body therapies. RELEVANCE (Seeinstructions): Findings from this proposal will provide important information for future clinical and mechanistic studies of mind-body therapies, particularly in cardiovascular disease populations, such as hypertension. A better understanding of the clinical benefits and mechanisms of mind-body-breathing practices will assist the development of targeted mind-body based treatments for lowering blood pressure.