Novel Strategies for Natural Products Synthesis

描述(由申请人提供)：该项目的目标是定义生物活性分子合成的新策略和新方法。我们构建的小分子可以为研究生物过程提供工具，并最终可能被用于开发新的疗法。这些研究还将有助于更好地了解有机官能团的反应性。具体地说，我们打算开发一种合成七萜化合物新芒果糖醇C和芒果糖醇A的通用策略。这些化合物具有抗肿瘤、抗菌和抗炎特性。我们还提出了一种新颖的碘介导的五环反应，该反应将用于合成一系列白藜芦醇衍生的天然产物。我们预计，这些新的五环化方法的发展将简化复杂分子的合成。天然产物的全合成推动了新方法和新战略的发展。反过来，这些新的发展将应用于其他生物和结构感兴趣的分子的合成。这些贡献将通过提供合成基础来帮助人类医学和化学生物学的进步。 与公共卫生相关：寻找新的和更有效的方法来构建小分子是一项重要的追求，将为化学、生物学和医学提供新的工具，并导致人类健康的改善。我们的目标是开发新的战略和方法，有效地制造具有制药重要性的小分子和天然产品。在这方面，我们特别感兴趣的是使用过渡金属的新的五元环形成反应。

DESCRIPTION (provided by applicant): The goal of this program is to define new strategies and methods for the synthesis of bioactive molecules. The small molecules that we construct can provide tools to study biological processes and may ultimately be used to develop new therapeutics. These studies will also lead to a better understanding of organic functional group reactivity. Specifically, we intend to develop a general strategy for the synthesis of the sesterterpene compounds neomangicol C and mangicol A. These compounds possess antitumor, antibacterial and anti-inflammatory properties. We also present a novel iodine-mediated pentannulation reaction that will be applied to the synthesis of a series of resveratrol-derived natural products. It is our anticipation that these new methodological developments for pentannulation will streamline the synthesis of complex molecules. The total synthesis of the natural products drives the development of new methods and strategies. In turn, these new developments will be applied to the synthesis of other molecules of biological and structural interest. These contributions will aid advances in human medicine and chemical biology by providing a synthesis foundation. PUBLIC HEALTH RELEVANCE: Finding new and more efficient ways to construct small molecules is an important pursuit that will provide new tools for chemical biology and medicine and lead to improvements in human health. Our goals are to develop new strategies and methods that efficiently build small molecules that are of pharmaceutical importance and natural products. In this regard, we are especially interested in new five-membered ring forming reactions using transition metals.