Analysis of Serum Exosomes in Patients with Colorectal and Breast Cancer

这项建议的一个主要优点是将两者的互补专业知识融合在一起 乳癌和结直肠癌实验室对外切体有着共同的兴趣，使真正的 合作建立一种临床适用的方法来测量来自 癌症患者的血清。我们预计，精选的可靠检测和精确量化 血清外切体中的蛋白质可能使乳腺癌和结直肠癌患者的早期诊断成为可能。 然而，试点项目将建立正常人血清外显子的正常标准，然后， 最初，将这些结果与早期和晚期结直肠癌患者以及晚期乳腺癌患者进行比较。 癌症。随着工作的进展，对血清外切体的分析可能被证明具有预测和预测作用。 在癌症患者管理中的价值[1]。

A major strength of this proposal is the blending of the complementary expertise of the two labs in breast and colorectal cancer with a shared interest in exosomes, enabling the formation of a true partnership to establish a clinically applicable method to measure selected proteins in exosomes from the serum of cancer patients. We anticipate that the reliable detection and precise quantification of selected proteins in serum exosomes may enable the eariier diagnosis of patients with breast and colorectal cancer. However, the pilot project will establish normal standards for serum exosomes in normal individuals, and then, initially, compare these results to patients with early and advanced colorectal cancer and advanced breast cancer. As the work progresses, analysis of serum exosomes may prove to have prognostic and predictive value in the management of patients with cancer [1].