Center for the Study of Reproductive Biology and Women's Health

描述（由申请人提供）：拟议中的生殖与不孕症研究专业合作中心项目（SCCPIR）专注于女性生殖生物学，Jeffrey W. Pollard博士为首席研究员。它是由一个由机构支持的“生殖生物学和妇女健康研究中心”演变而来的，该中心于2003年在阿尔伯特·爱因斯坦医学院成立，波拉德博士担任主任。该中心汇集了该机构在女性生殖方面的不同研究领域，形成了一个独特的互动小组，他们以翻译为重点。在过去的四年里，本中心的研究人员一直致力于撰写这份报告，并在此过程中定期召开会议，开展合作项目，并利用机构资金支持与女性生殖研究相关的临床奖学金培训。在这样做的过程中，所提议项目的PI都相互发表了，他们已经确定了几位研究员，将被带到教职员工中进行临床/基础科学研究。

DESCRIPTION (provided by applicant): The proposed Specialized Cooperative Center Program in Reproductive and Infertility Research (SCCPIR) is focused upon female reproductive biology with Dr. Jeffrey W. Pollard as Principal Investigator. It has evolved out of an institutional supported "Center for the Study of Reproductive Biology and Women's Health" founded in 2003 at the Albert Einstein College of Medicine with Dr. Pollard as Director. This Center drew together disparate strands of research in the female reproduction at the institution to form a distinct group of interactive individuals who have a translational focus. Investigators with this Center have worked for the last four years to develop this submission and in doing so have met regularly to undertake collaborative projects and used institutional funds to support clinical fellowship training relevant to the study of female reproduction. In doing so the PI's of the proposed projects have all published with one another and they have identified several fellows to be brought onto faculty to perform clinical/basic science research. The SCCPIR has four Projects (Projects 1 and 2 being clinical) and an administrative core as follows: Project 1. Dr. Jeffrey Pollard (PI) - Estrogen and Progesterone Regulation of Human Endometrial Cell Proliferation. Project 2. Dr. Nanette Santoro (PI) - Reproductive hormonal alterations in obesity. Project 3. Dr. Anne Etgen (PI) - IGF-I and Neuroendocrine Regulation of Female Reproductive Function. Project 4. Dr. Streamson Chua (PI) - Antagonistic actions of melanocortins and leptin on reproductive competence. A senior investigator leads all of these projects. There is integration amongst the projects through studies on the roles of obesity and nutrition in reproductive biology as well as the relationship between the insulin-like growth factor-1 axis and estrogen action. The PI, Dr. Jeffrey W. Pollard, is an internationally known researcher in reproductive biology having been, amongst other things, Chair of the Reproductive Tract Gordon Conference. He holds several senior administrative appointments in the College of Medicine and is well able to administer the proposed SCCPIR internally and to enable effective interactions with other SCCPIRs.