MRI Methods for Guiding Focused Ultrasound in the Brain

深部脑肿瘤的令人兴奋的潜力是能够用聚焦超声治疗它们， 而不损伤中间组织，并且不需要打开头部。MRI可以提供 通过出色的软组织对比度进行靶向、监测 磁共振测温技术，以及治疗后立即评估组织活力的方法。的 该项目的目的是改进这些MR方法。具体来说，我们的目标是a）改善焦点 B）改善温度成像，包括全脑覆盖和降低对 伪影，c）在存在钙化的情况下改善消融，以及d）测试一系列 超声波脉冲不会损伤脑组织，热固定发生在温度高于 60摄氏度此外，我们将研究DWI、MT、T1、CE和刚度加权上热损伤的外观 图像.

The exciting potential for deep-seated brain tumors is the ability to treat them with focused ultrasound, without damage to the intervening tissues, and without the need to open the head. MRI can provide the necessary control for these procedures through outstanding soft tissue contrast for targeting, monitoring techniques with MR thermometry, and the means to assess tissue viability immediately after treatment. The aims of this project are to improve these MR methods. Specifically, we aim to a) improve focal spot localization, b) improve temperature imaging including whole brain coverage and reduced sensitivity to artifacts, c) improved ablation in the presence of calcifications, and d) test the hypotheses that a series of ultrasound pulses do not damage brain tissue and that heat fixation occurs for temperatures greater than 60¿C. In addition, we will investigate the appearance of thermal lesions on DWI, MT, T1, CE, and stiffness weighted images.