VIRAL VECTOR CORE

病毒载体核心：主管-J.约翰斯顿 Vector Core的主要目标是为DERC中心成员提供最先进的 用于临床前研究的载体技术。为了促进载体的创建和生产， 专业人员，使用最先进的设施，将进行以下工作：1）生产病毒 衍生自腺相关病毒（AAV）、腺病毒和慢病毒的载体以及 生产用于基础研究的非病毒载体; 2）与DERC研究人员合作， 开发专门用于DERC成员的载体或重组病毒; 3）开发 基因转移载体，将是上级的那些前几代; 4）提交的 将生产的载体输送至生物测定核心，以确定载体的数量、纯度和效价 5）开发一个基于网络的数据库，使DERC成员能够要求 服务，监测病媒生产的状况，并获取有关 他们的实验室。

VIRAL VECTOR CORE: Director-J. Johnston The main objective of the Vector Core is to provide DERC center members access to state-of-theart vector technology for preclinical studies. In order to facilitate vector creation and production, the professional staff, using a state-of-the-art facility, will carry out the following: 1) Production of viral vectors derived from adeno-associated viruses (AAV), adenoviruses, and lentiviruses as well as the production of non-viral vectors for use in basic research; 2) Work with DERC Investigators to develop vectors or recombinant viruses specifically of use to DERC members; 3) Development of gene transfer vectors that will be superior to those of previous generations; 4) Submission of the vectors produced to the Bioassay Core to determine the quantity, purity and potency of the vectors produced; 5) Development of a web-based database to enable DERC members to request services, monitor the status of vector production, and access historical data on vectors produced by their laboratory.