Purchase of IVC Caging Systems for Mice and Rats in Dunning Hall

描述(申请人提供)：约翰霍普金斯大学(JHU)动物研究和资源副教务长办公室申请500,000美元的财政支持，购买总价格为521,379美元的单独通风笼架，用于在霍姆伍德校区Krieger艺术与科学学院Dunning Hall最近翻修的动物设施中安置无特定病原体(SPF)的大鼠和小鼠。邓宁堂地下室的一部分在2009年冬季进行了翻新，创建了4个动物收容室和1个程序/动物收容室，以及一个笼架洗涤室。其中两个动物拘留室将配备6-70笼Allentown单面IVC鼠架和两个6-40笼Allentown单面IVC鼠架。手术/动物等待室能够容纳两种架子，如果将来需要，还可以容纳动物手术的生物安全柜。这些动物室将被用来容纳繁殖动物和学习前被关押的动物。动物将被转移到列维大厅，安置和使用，列维大厅由一条地下隧道连接到邓宁厅。这两名调查人员将使用用这些G20赠款基金购买的笼子将动物安置在邓宁霍尔设施中，联邦政府的直接资金总额接近226万美元，其中188万美元来自美国国立卫生研究院。在邓宁大厅增加这种动物容纳能力将允许利维大厅的动物容纳空间用于支持校园内其他研究人员的研究项目，这些研究人员得到了美国国立卫生研究院560万美元的拨款支持。

DESCRIPTION (provided by applicant): This application from the Office of the Associate Provost for Animal Research and Resources at Johns Hopkins University (JHU) requests $500,000 in financial support toward the total purchase price of $521,379 for individually ventilated cage (IVC) racks for housing specific pathogen free (SPF) rats and mice in a recently renovated animal facility in Dunning Hall at the Krieger College of Arts and Sciences at the Homewood Campus. A portion of the basement of Dunning Hall was renovated during the winter of 2009 to create 4 animal holding and 1 procedure/animal holding rooms, and a cage rack wash down room. Two of the animal holding rooms will be equipped with 6-70 cage Allentown single sided IVC mouse racks and two with 6-40 cage Allentown single-sided IVC rat racks. The procedure/animal holding room is capable of holding 2 of either kind of rack and will also be able to hold a Biosafety cabinet for animal procedures if needed sometime in the future. These animal rooms will be used to hold breeding animals and animals being held prior to study. Animals will be transferred, housed and used in Levi Hall, which is connected by an underground tunnel to Dunning Hall. The two investigators who will have animals housed in the Dunning Hall facility using the caging purchased with these G20 grant funds have total direct cost Federal funding of almost $ 2.26 million, $ 1.88 million of which comes from the NIH. The addition of this animal holding capability in Dunning Hall will allow the animal holding space in Levi Hall to be used for supporting the research programs of the other investigators on the campus who have $ 5.6 million in grant support from the NIH.