EARLY DETECTION OF POLYCYSTIC OVARIAN SYNDROME

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 目的：建立多囊卵巢综合征(PCOS)的首个诊断试验。 多囊卵巢综合征(PCOS)以无排卵、异常不孕为特征 雄激素和其他激素的分泌，以及胰岛素抵抗。PCOS是最多的 常见的女性内分泌障碍，影响4%至7%的女性生殖 几年来，这种综合征占所有无排卵的75%。简而言之，PCOS有 令人震惊的不良生理、心理和经济后果 生殖健康。 我们正在开发一种新的“新陈代谢分析”方法来检测和统计模型 已证实的人体总代谢物池中分子子集的变化 是多囊卵巢综合征的可靠早期指标。 该方法将通过测量女性和恒河猴的生物标记物而得到。 威斯康星州国家灵长类研究中心的多囊卵巢综合征。这些动物一直是 在过去的二十年里得到了很好的刻画和研究。这个想法是用一个非人类 与人类样本平行建立多囊卵巢综合征的灵长类模型，开发一种新的诊断测试。 有了这一点，我们将开始分析患者样本，以开发人类多囊卵巢综合征的肖像。 我们的方法可以用来为各种其他疾病开发类似的测试。 我们将使用UWMadison独有的技术和资源的组合。我们将使用 稳定同位素、核磁共振和质谱学，以及先进的数学计算，所有这些 它以临床和医学为中心，具有广泛的临床应用。 这项研究使用了WNPRC动物服务中心。 三份出版物的准备工作正在进行中，正在申请专利。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To develop the first diagnostic test for PCOS. Polycystic ovary syndrome (PCOS) is marked by infertility due to anovulation, abnormal secretion of androgens and other hormones, and insulin resistance. PCOS is the most common female endocrine disorder, affecting 4 to 7 percent of women in their reproductive years, and the syndrome accounts for 75 percent of all anovulations. In short, PCOS has staggering adverse physiological, psychological and financial consequences for women's reproductive health. We are developing a novel "metabolic analysis" method to detect and statistically model changes in a subset of molecules within the body's total pool of metabolites that have proven to be reliable early indicators of PCOS. The method will derive from measuring biomarkers in women as well as in rhesus monkeys with PCOS at the Wisconsin National Primate Research Center. These animals have been well characterized and studied during the past two decades. The idea is to use a nonhuman primate model of PCOS in parallel with human samples to develop a novel diagnostic test. With this, we will begin to analyze patient samples to develop the portrait of PCOS in humans. Our approach could be used to develop similar tests for a variety of other diseases. We will use a combination of technologies and resources unique to UWMadison. We will use stable isotopes, NMR and mass spectroscopy, and advanced mathematical computation, all of which are centered around clinical and medical sciences with broad clinical applications. This research used WNPRC Animal Services. Preparation of three publications are in progress pending patent application.