Host-Microbe Interactions

描述（由申请人提供）：拟议的培训计划的主要目标是首先招募有才华和高度积极性的研究生，其次为他们提供一流的培训，这将使他们为学术研究的职业生涯做好准备，成为有竞争力的独立调查员。该计划教师的研究兴趣涵盖了关于宿主-微生物相互作用和发病机制相关主题的广泛问题，这使得进入实习生的实验系统，方法和研究主题的选择范围相当广泛。培训选项包括动物和人类系统，从而提高我们吸引和培养博士的能力。M.D.博士学生的研究生涯。拟议的培训补助金的另一个优势是参与教师的研究计划的质量。该提案包括19名资金充足的计划教师，他们在当前感兴趣的众多领域进行了富有成效，及时和充满活力的研究工作。特别的优势领域是细菌、寄生虫和病毒发病机制的分子遗传学;寄生虫的细胞和免疫生物学; B细胞活化和与T辅助细胞和淋巴因子的相互作用;粘膜免疫应答;宿主-病原体相互作用中的信号事件;参与抵抗感染性疾病的各种免疫机制，包括由细菌，真菌，寄生虫和逆转录病毒，如HIV和小鼠艾滋病（MAIDS）病毒;免疫治疗和疫苗设计。这些领域是追求使用现代遗传学，免疫学，生物化学和分子生物学技术的全方位。我们拥有出色的设施和资源，包括新的或翻新的实验室，以促进这些技术的应用。该提案还受益于强大的现有研究生课程的存在，导致博士学位。℃下分子发病机制的培训跨越六个部门，包括两个研究生课程-分子和细胞生物学以及实验和分子医学课程-前者包含大多数参与教师和学生。与该组织一致，在达特茅斯的分子发病机制研究生培训是一种跨学科的方法，是由一个高度互动的环境，其中学员定期接触到教师专业知识的不同领域，从临床到基础科学研究，在各种论坛，包括一些高级课程，每周研讨会系列和期刊俱乐部，和务虚会培育。

DESCRIPTION (provided by applicant): The primary goals of the proposed training program are first to recruit talented and highly-motivated graduate students and second to provide them with first-rate training that will prepare them for careers in academic research as competitive, independent investigators. The program faculty's research interests span a wide range of questions regarding host-microbe interactions and related topics in pathogenesis, which allows the entering trainee a considerable breadth of choice of experimental systems, approaches, and research topics. Training options include animal and human systems, thus enhancing our ability to attract and train Ph.D. and M.D./Ph.D. students for research careers. Another strength of the proposed training grant is the quality of the research programs of the participating faculty. This proposal includes 19 well-funded program faculty members who have productive, timely, and energetic research efforts in numerous areas of current interest. Particular areas of strength are molecular genetics of bacterial, parasitic, and viral pathogenesis; cellular and immunobiology of parasites; B cell activation and interaction with T helper cells and lymphokines; mucosal immune responses; signaling events in host-pathogen interactions; involvement of various immune mechanisms in resistance to infectious diseases including those caused by bacteria, fungi, parasites and retroviruses such as HIV and mouse AIDS (MAIDS) virus; immunotherapeutics and vaccine design. These areas are pursued using the full range of modern genetic, immunblogic, biochemical, and molecular biologic techniques. We have outstanding facilities and resources to facilitate the application of these techniques, including new or renovated laboratories. The proposal also benefits from the presence of strong existing graduate programs leading to the Ph.D. degree. Training in molecular pathogenesis spans six departments that encompass two graduate programs - Molecular and Cellular Biology and Program in Experimental and Molecular Medicine - with the former containing the majority of the participating faculty and students. Consistent with this organization, graduate training in molecular pathogenesis at Dartmouth is an interdisciplinary approach that is nurtured by a highly interactive environment in which the trainees are regularly exposed to diverse areas of faculty expertise, from clinical to basic science studies, in a variety of forums, including a number of advanced courses, weekly seminar series and journal clubs, and retreats.