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Genetic insights into atherosclerosis

Genetic insights into atherosclerosis
动脉粥样硬化的遗传学见解
批准号：
8557999
负责人：
PAUL M. HWANG
金额：
$44.54万
依托单位：
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8557999
关键词：
Arterial Fatty StreakAtherosclerosisBloodBlood specimenCholesterolGeneticGenetic TechniquesGenomicsGrantHumanImmune systemInflammationLegal patentMediator of activation proteinMolecularOxidative StressOxygenProteinsRheumatoid ArthritisSeverity of illnessTIS11 proteinTissue SampleTissuesZinc Fingershuman subjectinsightnoveltumorigenesis

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中文摘要
翻译
通过我们使用人类血液和动脉粥样硬化斑块组织样本的基因组研究，我们已经确定了动脉粥样硬化疾病严重程度的标记和胆固醇无关的他汀类药物治疗标记，该标记已获得使用专利。我们还发现三戊丙氨酸锌指蛋白36 （TTP）是局部组织炎症的中介，对炎症性关节炎和动脉粥样硬化很重要。由于氧化应激与炎症有关，是肿瘤发生和动脉粥样硬化的驱动因素，我们已经开始研究环境氧对动脉粥样硬化的影响。
英文摘要
Through our genomic studies using human blood and atherosclerotic plaque tissue samples, we have identified a marker of atherosclerosis disease severity and a cholesterol-independent marker of statin treatment, which has been granted a use patent. We have also identified tristetraprolin zinc finger protein 36 (TTP) as a mediator of localized tissue inflammation important for inflammatory arthritis and atherosclerosis. Because oxidative stress is associated with inflammation, a driver of both tumorigenesis and atherosclerosis, we have initiated studies to examine the effect of ambient oxygen on atherosclerosis.
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