FUNCTION AND PLASTICITY OF PREFRONTAL LOCAL CIRCUITS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 前额叶皮质神经元微电路的功能障碍被认为是一些主要的神经精神障碍，如精神分裂症的发病机制。持续神经元活动的产生和维持是这些前额叶回路的基本特征之一，这些前额叶回路支撑着许多前额叶功能，包括工作记忆。本项目的目的是研究1)前额叶微电路中突触的基本传递特性，2)突触可塑性，特别是峰时依赖性可塑性(STDP)，及其与持续神经元活动的相互作用，3)多巴胺能输入的调节作用和潜在的分子机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Dysfunction of the neuronal microcircuits in the prefrontal cortex is believed to underline the pathogenesis of some major neuropsychiatric disorders, such as schizophrenia. Generation and maintenance of persistent neuronal activity is one of essential features of these prefrontal circuits underlying many prefrontal functions, including working memory. The aims of this project are to investigate 1) the basic synaptic transmission properties in prefrontal microcircuits, 2) synaptic plasticity, especially spike timing-dependent plasticity (STDP), and its interaction with persistent neuronal activity, 3) the modulatory effects of dopaminergic input and underlying molecular mechanisms.