MOSAIC VACCINE-ELICITED IMMUNE RESPONSES IN RHESUS MONKEYS

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 成功的HIV疫苗的创建将需要开发一种免疫原，该免疫原将产生具有足够跨分支宽度的细胞免疫，以应对病毒的极端遗传多样性。最近有人提出，基于集中的HIV基因序列的疫苗可能会为流行的HIV病毒株的遗传异质性所带来的问题提供解决方案。 共有和多价嵌合免疫原都是基于集中的基因序列。本研究旨在探讨与共识免疫原相比，多价嵌合体疫苗接种产生的CD 4+和CD 8 + T淋巴细胞应答的广度。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Creation of a successful HIV vaccine will require development of an immunogen that will generate cellular immunity with sufficient cross-clade breadth to deal with the extreme genetic diversity of the virus. Recently it has been suggested that vaccines based on centralized HIV gene sequences might provide a solution to the problem posed by the genetic heterogeneity of the circulating strains of HIV. Both consensus and polyvalent mosaic immunogens are based on centralized gene sequences. The present study was designed to explore the breadth of CD4+ and CD8+ T lymphocyte responses generated by vaccination with polyvalent mosaic as compared to vaccination with consensus immunogens.