FOOD-BORNE TULAREMIA THREAT ASSESSMENT

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 革兰氏阴性球杆菌土拉热弗朗西斯菌是土拉菌病的病原体。 天然水库包括小型哺乳动物，如地松鼠，野兔，田鼠，麝鼠，水鼠，兔子和其他啮齿动物。 这种疾病通过直接接触或节肢动物媒介传播，从受感染的水库和其他小型脊椎动物传播给人类。 兔热病表现为多种方式，包括接种部位溃疡、咽炎、淋巴结病和肺炎。 立即使用适当的抗生素治疗可以减少危及生命的肺炎的可能性。 F.土拉热是A类病原体。 据报告，吸入该制剂的感染剂量仅为10个微生物。关于胃肠道土拉菌病的死亡率的信息知之甚少。 该项目的最终目标是描述非人灵长类动物疾病的发病机制，并评估氟喹诺酮治疗在预防致命疾病方面的有效性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The gram-negative coccobacillus Francisella tularensis is the causative agent of tularemia. The natural reservoir includes small mammals such as ground squirrels, hares, voles, muskrats, water rats, rabbits and other rodents. This illness is spread to humans from infected reservoirs and other small vertebrates through direct contact or transmission from an arthropod vector. Tularemia is manifested in various ways including ulcers at the site of inoculation, pharyngitis, lymphadenopathy, and pneumonia. Immediate treatment with appropriate antibiotics can reduce the possibility of life-threatening pneumonia. F. tularensis is a category A agent. The infectious dose for this agent by inhalation is reported to be as few as 10 organisms. Much less information is known about the mortality of GI tularemia. The ultimate goal for this project is to characterize pathogenesis of disease in nonhuman primates and to assess effectiveness of fluoroquinolone treatment in protecting against lethal disease.